Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study.
Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study.
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DOI：
10.1111/j.1399-5618.2008.00617.x
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发表时间：
2008-09
影响因子：
5.4
通讯作者：
Cohen MS
中科院分区：
文献类型：
--
作者：
Altshuler L;Bookheimer S;Townsend J;Proenza MA;Sabb F;Mintz J;Cohen MS
探讨双相抑郁症患者前额叶皮层和杏仁核的神经活动。11名双相I型抑郁症患者和17名正常人在执行一项已知会激活前额皮质和杏仁核的任务时，接受了功能性磁共振成像（fMRI）检查。采用统计参数映射（SPM）确定受试者在匹配中性或消极情绪的面孔（匹配条件）或匹配几何形状（控制条件）时的全脑激活模式。在二级随机效应分析中，使用匹配条件与对照条件的每组对比。组间随机效应分析显示双相抑郁症患者左右眶额皮质（BA47）和右背外侧前额皮质（DLPFC） （BA9）显著衰减。此外，随机效应分析显示，与对照组相比，双相抑郁症患者左侧眶额皮质（BA10）的激活显著增加。组内对比显示，对照组的杏仁核有明显的激活，而双相抑郁受试者的杏仁核没有明显的激活。然而，各组之间的杏仁核差异并不显著。双相抑郁症与双侧眼窝前额叶（BA47）激活减弱、右侧DLPFC （BA9）激活减弱和左侧眼窝前额叶（BA10）激活升高相关。在躁狂中也有BA47衰减的报道，因此可能代表了该疾病的一种特征。左前额叶（BA10）激活增加可能是双相抑郁症的状态标志。我们的研究结果表明，双相情感障碍中情绪依赖性和疾病依赖性脑功能异常之间存在分离。
To investigate neural activity in prefrontal cortex and amygdala during bipolar depression. Eleven bipolar I depressed and 17 normal subjects underwent functional magnetic resonance imaging (fMRI) while performing a task known to activate prefrontal cortex and amygdala. Whole brain activation patterns were determined using statistical parametric mapping (SPM) when subjects matched faces displaying neutral or negative affect (match condition) or matched a geometric form (control condition). Contrasts for each group for the match versus control conditions were used in a second-level random effects analysis. Random effects between-group analysis revealed significant attenuation in right and left orbitofrontal cortex (BA47) and right dorsolateral prefrontal cortex (DLPFC) (BA9) in bipolar depressed subjects. Additionally, random effects analysis showed a significantly increased activation in left lateral orbitofrontal cortex (BA10) in the bipolar depressed versus control subjects. Within-group contrasts demonstrated significant amygdala activation in the controls and no significant amygdala activation in the bipolar depressed subjects. The amygdala between-group difference, however, was not significant. Bipolar depression is associated with attenuated bilateral orbitofrontal (BA47) activation, attenuated right DLPFC (BA9) activation and heightened left orbitofrontal (BA10) activation. BA47 attenuation has also been reported in mania and may thus represent a trait feature of the disorder. Increased left prefrontal (BA10) activation may be a state marker to bipolar depression. Our findings suggest dissociation between mood-dependent and disease-dependent functional brain abnormalities in bipolar disorder.
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影响因子：
16.2
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