Parallel retention of Pdx2 genes in cartilaginous fish and coelacanths.
Parallel retention of Pdx2 genes in cartilaginous fish and coelacanths.
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DOI：
10.1093/molbev/msq121
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发表时间：
2010-10
影响因子：
10.7
通讯作者：
Holland PW
中科院分区：
文献类型：
--
作者：
Mulley JF;Holland PW
Pdx 1或Ipf 1基因编码一种重要的含同源结构域的蛋白，在胰腺发育和功能中起关键作用。人类PDX 1的突变与胰腺的发育缺陷和疾病有关。包括基因组测序在内的广泛研究表明，Pdx 1是哺乳动物、鸟类、两栖动物和鳍鱼中唯一的基因家族成员，除了硬骨鱼，该基因与Gsx 1和Cdx 2一起沿着形成ParaHox基因簇的一部分。然而，ParaHox簇是4倍基因组重复的残余;其他三个ParaHox旁系同源物在迄今为止检查的所有脊椎动物基因组中缺乏Pdx样基因。我们已经使用细菌人工染色体克隆和同线性分析表明，生活的有颌脊椎动物的祖先实际上有更多的ParaHox基因，包括两个Pdx基因（Pdx 1和Pdx 2）。令人惊讶的是，这两个Pdx基因在两个相当遥远的亲缘关系中平行保留，软骨鱼（鲨鱼，冰鞋和嵌合体）和印度尼西亚腔棘鱼，Latimeria menadoensis。Pdx 2基因在鳍鱼和四足动物中分别丢失。
The Pdx1 or Ipf1 gene encodes an important homeodomain-containing protein with key roles in pancreas development and function. Mutations in human PDX1 are implicated in developmental defects and disease of the pancreas. Extensive research, including genome sequencing, has indicated that Pdx1 is the only member of its gene family in mammals, birds, amphibians, and ray-finned fish, and with the exception of teleost fish, this gene forms part of the ParaHox gene cluster along with Gsx1 and Cdx2. The ParaHox cluster, however, is a remnant of a 4-fold genome duplication; the three other ParaHox paralogues lack a Pdx-like gene in all vertebrate genomes examined to date. We have used bacterial artificial chromosome cloning and synteny analysis to show that the ancestor of living jawed vertebrates in fact had more ParaHox genes, including two Pdx genes (Pdx1 and Pdx2). Surprisingly, the two Pdx genes have been retained in parallel in two quite distantly related lineages, the cartilaginous fish (sharks, skates, and chimeras) and the Indonesian coelacanth, Latimeria menadoensis. The Pdx2 gene has been lost independently in ray-finned fish and in tetrapods.
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影响因子：
2.6
作者：
Assouline, B;Nguyen, V;Scharfmann, R
通讯作者：
Scharfmann, R
影响因子：
64.8
作者：
JONSSON, J;CARLSSON, L;EDLUND, H
通讯作者：
EDLUND, H
影响因子：
2.9
作者：
Ferrier, DEK;Holland, PWH
通讯作者：
Holland, PWH
影响因子：
64.8
作者：
Brooke, NM;Garcia-Fernàndez, J;Holland, PWH
通讯作者：
Holland, PWH
影响因子：
2.5
作者：
Illes, Jean C.;Winterbottom, Emily;Isaacs, Harry V.
通讯作者：
Isaacs, Harry V.