Spillover of West Caucasian Bat Lyssavirus (WCBV) in a Domestic Cat and Westward Expansion in the Palearctic Region.
Spillover of West Caucasian Bat Lyssavirus (WCBV) in a Domestic Cat and Westward Expansion in the Palearctic Region.
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DOI：
10.3390/v13102064
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发表时间：
2021-10-14
期刊：
影响因子：
--
通讯作者：
De Benedictis P
中科院分区：
文献类型：
--
作者：
Leopardi S;Barneschi E;Manna G;Zecchin B;Priori P;Drzewnioková P;Festa F;Lombardo A;Parca F;Scaravelli D;Maroni Ponti A;De Benedictis P
2020年6月，意大利阿雷佐的一只死于神经系统疾病的猫被诊断出感染了西高加索蝙蝠lyssavv （WCBV）。该病毒与2002年从俄罗斯弯翅蝙蝠身上发现的参考分离物在整个基因组中保持了高度的同一性。我们采用了国家法规建议的控制措施，通过目视检查、生物声学分析和摄像机陷阱调查了猫和蝙蝠之间可能存在的界面，并对蝙蝠进行了主动和被动监测，以追踪感染源。接触过猫的人接受了全面的接触后预防，而动物则接受了6个月的隔离。一年后，他们都很健康。在猫家附近的隧道中，我们发现了一组弯翼蝙蝠，在四次采样中显示出对WCBV的病毒中和抗体，但在唾液拭子中没有病毒。其他种类蝙蝠的尸体均呈阴性。这种对非飞行哺乳动物WCBV的描述证实，在缺乏预防和治疗措施的情况下，该病毒可引起临床狂犬病，并突出表明缺乏针对不同狂犬病毒的国际指导方针。我们发现弯翼蝙蝠是最可能的感染源，证明了这些蝙蝠与城市地区的宠物/人类之间的侵犯，并确认自由放养的猫是公共卫生和保护的潜在危害。
In June 2020, a cat from Arezzo (Italy) that died from a neurological disease was diagnosed with West Caucasian Bat Lyssavirus (WCBV). The virus retained high identity across the whole-genome with the reference isolate found in 2002 from a Russian bent-winged bat. We applied control measures recommended by national regulations, investigated a possible interface between cats and bats using visual inspections, bioacoustics analyses and camera trapping and performed active and passive surveillance in bats to trace the source of infection. People that were exposed to the cat received full post-exposure prophylaxis while animals underwent six months of quarantine. One year later, they are all healthy. In a tunnel located near the cat’s house, we identified a group of bent-winged bats that showed virus-neutralizing antibodies to WCBV across four sampling occasions, but no virus in salivary swabs. Carcasses from other bat species were all negative. This description of WCBV in a non-flying mammal confirms that this virus can cause clinical rabies in the absence of preventive and therapeutic measures, and highlights the lack of international guidelines against divergent lyssaviruses. We detected bent-winged bats as the most probable source of infection, testifying the encroachment between these bats and pets/human in urban areas and confirming free-ranging cats as potential hazard for public health and conservation.
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影响因子：
11.8
作者：
da Rosa, Elizabeth S. T.;Kotait, Ivanete;Vasconcelos, Pedro F. C.
通讯作者：
Vasconcelos, Pedro F. C.
影响因子：
11.8
作者：
Coertse J;Grobler CS;Sabeta CT;Seamark ECJ;Kearney T;Paweska JT;Markotter W
通讯作者：
Markotter W
影响因子：
1.7
作者：
Gurun, Kanat;Furman, Andrzej;Bilgin, Rasit
通讯作者：
Bilgin, Rasit
影响因子：
3.8
作者：
Johnson, Nicholas;Vos, Ad;Fooks, Anthony R.
通讯作者：
Fooks, Anthony R.
影响因子：
14.9
作者：
Dereeper A;Guignon V;Blanc G;Audic S;Buffet S;Chevenet F;Dufayard JF;Guindon S;Lefort V;Lescot M;Claverie JM;Gascuel O
通讯作者：
Gascuel O