Separation of risks and benefits of seafood intake.
Separation of risks and benefits of seafood intake.
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DOI：
10.1289/ehp.9738
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发表时间：
2007-03
影响因子：
10.4
通讯作者：
Weihe P
中科院分区：
文献类型：
--
作者：
Budtz-Jørgensen E;Grandjean P;Weihe P
鱼类和海产品提供重要的营养素，但也可能含有有毒污染物，如甲基汞。因此，反对污染物的建议可能与饮食建议相冲突。在解决这一难题时，大多数流行病学研究几乎没有提供指导，因为它们要么解决营养益处，要么解决汞毒性，而不是两者兼而有之。来自相同食物来源的两次暴露对相同健康结果的影响提供了混淆的典型例子。为了探索这种偏见的程度，我们采用结构方程模型的数据从一个前瞻性研究的发展甲基汞神经毒性在法罗群岛。与未调整的结果相比，调整孕妇在怀孕期间摄入鱼类所带来的益处导致产前甲基汞暴露的影响增加。饮食调查问卷的回答可能是一个不精确的代理海鲜营养素转移到胎儿，这种不精确性可能会偏见的混淆调整汞效应估计。我们在敏感性分析中探讨了这种偏倚的大小，假设误差方差范围。在现实的不精确性水平，汞相关的赤字增加了2倍，与未经调整的影响相比。这些结果表明，不受控制的混杂从一个有益的参数，这种混杂的不精确性，可能会导致实质性低估的毒性暴露的影响。因此，来自鱼类和海产品的甲基汞暴露的不利影响可能会被观察性研究的未经调整的结果低估，这种偏差的程度将取决于研究。
Fish and seafood provide important nutrients but may also contain toxic contaminants, such as methylmercury. Advisories against pollutants may therefore conflict with dietary recommendations. In resolving this conundrum, most epidemiologic studies provide little guidance because they address either nutrient benefits or mercury toxicity, not both. Impact on the same health outcomes by two exposures originating from the same food source provides a classical example of confounding. To explore the extent of this bias, we applied structural equation modeling to data from a prospective study of developmental methylmercury neurotoxicity in the Faroe Islands. Adjustment for the benefits conferred by maternal fish intake during pregnancy resulted in an increased effect of the prenatal methylmercury exposure, as compared with the unadjusted results. The dietary questionnaire response is likely to be an imprecise proxy for the transfer of seafood nutrients to the fetus, and this imprecision may bias the confounder-adjusted mercury effect estimate. We explored the magnitude of this bias in sensitivity analysis assuming a range of error variances. At realistic imprecision levels, mercury-associated deficits increased by up to 2-fold when compared with the unadjusted effects. These results suggest that uncontrolled confounding from a beneficial parameter, and imprecision of this confounder, may cause substantial underestimation of the effects of a toxic exposure. The adverse effects of methylmercury exposure from fish and seafood are therefore likely to be underestimated by unadjusted results from observational studies, and the extent of this bias will be study dependent.
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影响因子：
3.4
作者：
Gochfeld, M;Burger, J
通讯作者：
Burger, J
影响因子：
2
作者：
Budtz-Jorgensen, E;Keiding, N;White, RF
通讯作者：
White, RF
影响因子：
10.4
作者：
Grandjean P;Budtz-Jørgensen E;Jørgensen PJ;Weihe P
通讯作者：
Weihe P
影响因子：
11.4
作者：
Sakamoto, M;Kubota, M;Satoh, H
通讯作者：
Satoh, H
影响因子：
4.2
作者：
Clarkson, TW;Strain, JJ
通讯作者：
Strain, JJ