The current status and trend of the functional magnetic resonance combined with stimulation in animals.

The current status and trend of the functional magnetic resonance combined with stimulation in animals.
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DOI:
10.3389/fnins.2022.963175
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发表时间:
2022
影响因子:
4.3
通讯作者:
Liang, Shengxiang
Liang, Shengxiang
中科院分区:
医学2区
文献类型:
--
作者:
Huang, Jiayang;Zhang, Yusi;Zhang, Qi;Wei, Linxuan;Zhang, Xiwen;Jin, Caiping;Yang, Junchao;Li, Zuanfang;Liang, Shengxiang

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功能磁共振成像(functional magnetic resonance imaging, fMRI)作为一种非辐射、非侵入性的成像技术,在研究人类和动物模型的血氧激活水平和大脑功能连通性方面具有优异的效果。与静息状态fMRI相比,fMRI联合刺激可以评估大脑特定区域的激活情况和特定通路的连通性,获得更好的信号捕获,目的明确,结果更显著。为了研究脑在特定状态下的激活,人们提出了多种功能磁共振成像方法和特定刺激范式,如电刺激、机械刺激、视觉刺激、嗅觉刺激和直接脑刺激。本文综述了fMRI结合不同刺激方法对动物脑激活的研究。综述了不同刺激条件下的仪器、实验参数、麻醉及动物模型。这一发现将为fMRI结合刺激估计脑特异性激活的研究提供参考。
As a non-radiative, non-invasive imaging technique, functional magnetic resonance imaging (fMRI) has excellent effects on studying the activation of blood oxygen levels and functional connectivity of the brain in human and animal models. Compared with resting-state fMRI, fMRI combined with stimulation could be used to assess the activation of specific brain regions and the connectivity of specific pathways and achieve better signal capture with a clear purpose and more significant results. Various fMRI methods and specific stimulation paradigms have been proposed to investigate brain activation in a specific state, such as electrical, mechanical, visual, olfactory, and direct brain stimulation. In this review, the studies on animal brain activation using fMRI combined with different stimulation methods were retrieved. The instruments, experimental parameters, anesthesia, and animal models in different stimulation conditions were summarized. The findings would provide a reference for studies on estimating specific brain activation using fMRI combined with stimulation.
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