Contaminant‐related disruption of vitamin a dynamics in free‐ranging harbor seal (Phoca vitulina) pups from british columbia, canada, and washington state, usa
Contaminant‐related disruption of vitamin a dynamics in free‐ranging harbor seal (Phoca vitulina) pups from british columbia, canada, and washington state, usa
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来自加拿大不列颠哥伦比亚省和美国华盛顿州的自由放养斑海豹 (Phoca vitulina) 幼崽中与污染物相关的维生素 A 动态破坏
DOI：
10.1002/etc.5620191132
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发表时间：
2000
影响因子：
4.1
通讯作者：
P. Ross
中科院分区：
文献类型：
--
作者：
W. Simms;S. Jeffries;M. Ikonomou;P. Ross
海洋哺乳动物可以通过饮食生物积累高浓度的亲脂性环境污染物，如多氯联苯（PCB），多氯二苯并帕拉二恶英（PCDD）和多氯二苯并呋喃（PCDF）。实验室和野生动物研究都表明，这些持久性化学物质可以破坏维生素A（视黄醇）的调节，维生素A是免疫功能，生殖，生长和发育所需的饮食激素。为了确定环境污染物是否会影响自由放养的斑海豹（Phoca vitulina）的循环维生素A动力学，我们从加拿大不列颠哥伦比亚省和美国华盛顿州活体捕获了61只幼海豹，并获得了血液和脂肪活检样本。来自华盛顿州的港海豹幼崽比来自不列颠哥伦比亚省的海豹幼崽受多氯联苯总污染的程度高出6倍，并且循环中的视黄醇水平明显较低。然而，当数据进行校正的差异，护理状态和未分组的数据集进行分析，循环视黄醇水平呈正相关，污染物水平的非护理幼崽的脂肪。视黄醇的增加可能是由于暴露于乳源性污染物后肝脏维生素A储存进入循环所致;这在实验暴露的实验室动物中观察到。在我们的研究中观察到的与污染物相关的维生素A动力学破坏发生在生长和发育需要维生素A的时候。
Marine mammals can bioaccumulate high concentrations of lipophilic environmental contaminants, such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo‐para‐dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), through the diet. Both laboratory and wildlife studies have shown that these persistent chemicals can disrupt the regulation of vitamin A (retinol), a dietary hormone required for immune function, reproduction, growth, and development. To determine whether environmental contaminants affect the circulatory vitamin A dynamics of free‐ranging harbor seals (Phoca vitulina), we live‐captured 61 pups from British Columbia, Canada, and Washington State, USA, and obtained blood and blubber biopsy samples. Harbor seal pups from Washington State were six times more contaminated with total PCBs than pups from British Columbia and had significantly lower circulatory retinol levels. However, when data were corrected for differences in nursing status and analyzed as ungrouped sets of data, circulatory retinol levels were positively correlated with contaminant levels in the blubber of nonnursing pups. This increase in retinol may have resulted from a mobilization of liver vitamin A stores into circulation following exposure to milk‐derived contaminants; this has been observed in laboratory animals exposed experimentally. The contaminant‐related disruption of vitamin A dynamics observed in our study occurs at a time when vitamin A is required for growth and development.
四氯二苯并-对-二恶英（TCDD）对大鼠视黄酸葡萄糖醛酸化的影响。
DOI：
10.1016/0304-4165(89)90134-7
发表时间：
1989
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bank,PA;Salyers,KL;Zile,MH
通讯作者：
Zile,MH
六氯联苯对大鼠维生素 A 稳态的影响。
DOI：
10.1016/s0304-4165(89)80050-9
发表时间：
1989
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bank,PA;Cullum,ME;Jensen,RK;Zile,MH
通讯作者：
Zile,MH
竖琴海豹 (Phoca groenlandica)、冠海豹 (Cystophora cristata) 和加州海狮 (Zalophus californianus) 肝脏中的视黄醇脂肪酰酯（维生素 A）。
DOI：
10.1139/o92-123
发表时间：
1992
期刊：
Biochemistry and cell biology = Biochimie et biologie cellulaire
影响因子：
--
作者：
Ball,MD;Nizzi,CP;Furr,HC;Olson,JA;Oftedal,OT
通讯作者：
Oftedal,OT