Making a grade: Sonic Hedgehog signalling and the control of neural cell fate.
Making a grade: Sonic Hedgehog signalling and the control of neural cell fate.
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成绩：声音刺猬信号传导和神经细胞命运的控制。
DOI：
10.1038/emboj.2009.12
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发表时间：
2009-03-04
期刊：
影响因子：
11.4
通讯作者：
Briscoe, James
中科院分区：
文献类型：
--
作者：
Briscoe, James
我祖父曾经告诉我，你永远不应该做任何可能为你赢得奖牌的事情。这个建议来自他在军队的时候，虽然他是一个人的意见，我非常尊重，这是一个建议，我从来没有想过会相关的我作为一个科学家。在我的辩护中，赢得奖牌从来不是我的意图或野心：当我收到EMBO的电子邮件通知我获得金牌时，没有人比我更惊讶和高兴了。事实上，回顾过去，我可以诚实地说，我从来没有打算或野心成为一名研究科学家。尽管我现在的一两个同事在学会走路、阅读或说出“终身职位委员会的决定”之前，似乎已经有了结构良好的职业规划，但我没有。和我怀疑的许多科学家一样，我偶然陷入了研究。我喜欢在学校的科学课上做得相当好，所以在考虑大学时选择科学科目是很明显的。最后我去了沃里克大学学习微生物学和病毒学，这门课涉及到大量的分子生物学。细菌和病毒生命的优雅和复杂性，以及在分子水平上研究这些生物体的方法，似乎可以将复杂性转化为简单、直接的功能解释，这让我着迷。在卡迪夫的阿默舍姆国际公司（现为通用电气医疗集团）工作的一年时间强化了我的这一观点，也激发了我对一些适当研究的兴趣。回到沃里克大学的最后一年，我特别惊讶于从病毒和病毒感染的研究中，我们对真核细胞的工作机制了解了很多。
My grandfather once told me that you should never do anything that might win you a medal. This advice came from his time in the military and although he was a man whose opinion I respected greatly, this was one piece of advice that I never thought would be relevant to me as a scientist. In my defence, it was never my intention or ambition to win a medal: no one could have been more surprised and delighted than I was when I received the email from EMBO informing me that I had won the Gold Medal. Indeed, looking back, I can honestly say it was never my intention or ambition to become a research scientist. Although one or two of my current colleagues appear to have had wellstructured career plans before they could walk, read or say ‘tenure committee decision’I did not. Similar to many scientists I suspect, I accidentally fell into research. I enjoyed and did reasonably well in science classes at school, so it was obvious to choose a science subject when thinking about university. I ended up at Warwick University studying Microbiology and Virology, a course that involved a great deal of molecular biology. The elegance and complexity of bacterial and viral life and the way in which studying these organisms at a molecular level seemed to resolve the complexity to simple, straightforward explanations of function captivated me. An intercalated year spent working at Amersham International in Cardiff (now GE Healthcare) reinforced this view and whetted my appetite for some proper research. Back at Warwick for my final year, I was particularly struck by how much had been learned about the mechanism at work in eukaryotic cells from the study of viruses and viral infections.
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影响因子：
3.5
作者：
Böse, J;Grotewold, L;Rüther, U
通讯作者：
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影响因子：
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作者：
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