Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling.

Mitogen-Activated Protein Kinase Cascades in Plant Hormone Signaling.
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植物激素信号传导中的丝裂原活化蛋白激酶级联反应

DOI:
10.3389/fpls.2018.01387
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发表时间:
2018
影响因子:
5.6
通讯作者:
Ludwikow A
Ludwikow A
中科院分区:
生物学2区
文献类型:
--
作者:
Jagodzik P;Tajdel-Zielinska M;Ciesla A;Marczak M;Ludwikow A

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在所有真核细胞中,丝裂原活化蛋白激酶(MAPK)模块通过下游信号靶标的磷酸化在环境和发育信号转导中发挥关键作用,这些下游信号靶标包括其他激酶、酶、细胞骨架蛋白或转录因子。一个典型的MAPK级联由至少三个顺序作用的丝氨酸/苏氨酸激酶组成,一个MAP激酶(MAPKKK),一个MAPKK(MAPKK),最后是MAPK(MAPK)本身,每个MAPK都会磷酸化,从而激活级联中的下一个激酶。最近我们对激素信号通路的了解取得了进展,导致了新的调控系统的发现。特别是,这项研究揭示了各种信号通路的蛋白质成分之间的串扰的新角色,以及这种串扰在多种细胞过程中的参与。在这里,我们提供了目前的激素信号模型和机制的概述,特别强调了MAPK在细胞信号网络中的作用。一句话总结:在这篇综述中,我们重点介绍了MAPK级联和植物激素信号通路之间的串扰机制,并总结了MAPK在各种细胞过程中的调控和功能的最新研究成果。
Mitogen-activated protein kinase (MAPK) modules play key roles in the transduction of environmental and developmental signals through phosphorylation of downstream signaling targets, including other kinases, enzymes, cytoskeletal proteins or transcription factors, in all eukaryotic cells. A typical MAPK cascade consists of at least three sequentially acting serine/threonine kinases, a MAP kinase kinase kinase (MAPKKK), a MAP kinase kinase (MAPKK) and finally, the MAP kinase (MAPK) itself, with each phosphorylating, and hence activating, the next kinase in the cascade. Recent advances in our understanding of hormone signaling pathways have led to the discovery of new regulatory systems. In particular, this research has revealed the emerging role of crosstalk between the protein components of various signaling pathways and the involvement of this crosstalk in multiple cellular processes. Here we provide an overview of current models and mechanisms of hormone signaling with a special emphasis on the role of MAPKs in cell signaling networks. One-sentence summary: In this review we highlight the mechanisms of crosstalk between MAPK cascades and plant hormone signaling pathways and summarize recent findings on MAPK regulation and function in various cellular processes.
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