MicroRNA-9 expression is a prognostic biomarker in patients with osteosarcoma.
MicroRNA-9 expression is a prognostic biomarker in patients with osteosarcoma.
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DOI：
10.1186/1477-7819-12-195
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发表时间：
2014-06-27
影响因子：
3.2
通讯作者：
Wu ZH
中科院分区：
文献类型：
--
作者：
Xu SH;Yang YL;Han SM;Wu ZH
本研究旨在检测骨肉瘤组织和正常骨组织中微小RNA-9（miR-9）的表达水平，探讨miR-9表达与骨肉瘤患者临床病理特征及预后的关系。采用实时定量分析检测骨肉瘤组织和相应非癌组织中miR-9的表达水平。使用 Kaplan-Meier 方法和对数秩检验确定患者生存率的差异。 Cox比例风险回归分析用于预后值的单变量和多变量分析。与非癌性骨组织相比，骨肉瘤组织中miR-9的表达水平显着升高（P<0.001）。我们发现miR-9的表达水平与肿瘤大小（P = 0.011）、临床分期（P = 0.009）和远处转移（P < 0.001）显着相关。 Kaplan-Meier曲线显示，miR-9低表达患者的生存期明显长于miR-9高表达患者（P = 0.0017）。多变量分析表明miR-9表达水平（P = 0.002）是总体生存的独立预后因素。我们的研究结果表明，miR-9表达增加与骨肉瘤的侵袭性进展有很强的相关性，其过度表达是影响总体生存的统计学上显着的危险因素，这表明miR-9表达增加可能是肿瘤进展和骨肉瘤预后的有价值的标志物。
The purpose of the present study was to examine the expression levels of microRNA-9 (miR-9) in osteosarcoma tissues and normal bone tissues, and investigate the relationships between miR-9 expression, clinicopathological features and the prognosis of patients with osteosarcoma. The expression levels of miR-9 in osteosarcoma tissues and corresponding non-cancerous tissues were detected using a real-time quantitative assay. Differences in patient survival were determined using the Kaplan–Meier method and a log-rank test. A Cox proportional hazards regression analysis was used for univariate and multivariate analyses of prognostic values. Compared to non-cancerous bone tissues, the expression levels of miR-9 in osteosarcoma tissues were significantly elevated (P < 0.001). We found that the expression level of miR-9 was significantly associated with tumor size (P = 0.011), clinical stage (P = 0.009) and distant metastasis (P < 0.001). The Kaplan–Meier curve showed that patients with low miR-9 expression survived significantly longer than patients with high miR-9 expression (P = 0.0017). Multivariate analysis suggested that miR-9 expression level (P = 0.002) is an independent prognostic factors for overall survival. The findings of our study suggest that increased miR-9 expression has a strong correlation with the aggressive progression of osteosarcoma and its overexpression is a statistically significant risk factor affecting overall survival, suggesting that increased miR-9 expression could be a valuable marker of tumor progression and for prognosis of osteosarcoma.
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影响因子：
2.9
作者：
Hu, Hao;Zhang, Yi;Cai, Lin
通讯作者：
Cai, Lin
microRNA-9通过靶向Cyclin D1和Ets1抑制胃癌细胞的增殖、侵袭和转移
影响因子：
3.7
作者：
Zheng L;Qi T;Yang D;Qi M;Li D;Xiang X;Huang K;Tong Q
通讯作者：
Tong Q
DOI：
10.1111/j.1750-3639.2008.00184.x
发表时间：
2009-07
期刊：
Brain pathology (Zurich, Switzerland)
影响因子：
--
作者：
Nass D;Rosenwald S;Meiri E;Gilad S;Tabibian-Keissar H;Schlosberg A;Kuker H;Sion-Vardy N;Tobar A;Kharenko O;Sitbon E;Lithwick Yanai G;Elyakim E;Cholakh H;Gibori H;Spector Y;Bentwich Z;Barshack I;Rosenfeld N
通讯作者：
Rosenfeld N
影响因子：
3.7
作者：
Zhou X;Marian C;Makambi KH;Kosti O;Kallakury BV;Loffredo CA;Zheng YL
通讯作者：
Zheng YL
影响因子：
8
作者：
Hildebrandt, M. A. T.;Gu, J.;Wu, X.
通讯作者：
Wu, X.