Association of Changes in Abdominal Fat Quantity and Quality With Incident Cardiovascular Disease Risk Factors.
Association of Changes in Abdominal Fat Quantity and Quality With Incident Cardiovascular Disease Risk Factors.
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DOI：
10.1016/j.jacc.2016.06.067
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发表时间：
2016-10-04
影响因子：
24
通讯作者：
Fox CS
中科院分区：
文献类型：
--
作者：
Lee JJ;Pedley A;Hoffmann U;Massaro JM;Fox CS
皮下脂肪组织(SAT)和内脏脂肪组织(VAT)与心脏代谢不良的风险相关。这项研究探讨了腹部脂肪数量和质量的变化与心血管疾病(CVD)危险因素变化的关联程度。研究参与者(n=1,106；44.1%的女性；平均基线年龄45.1岁)来自弗雷明翰心脏研究第三代队列，他们参加了计算机断层扫描(CT)子研究考试1和2。参与者平均被跟踪了6.1年。腹部脂肪组织体积以cm3为单位，Hounsfield单位(HU)为单位，通过CT获取的腹部扫描来确定。平均脂肪体积变化，SAT组增加602 cm~3，VAT组增加703 cm~3，脂肪衰减变化分别减少5.5HU和0.07HU。脂肪体积的增加和脂肪衰减的减少与心血管危险因素的不利变化相关。脂肪体积增加另外500立方米与高血压(OR：SAT：1.21；OR：1.30，VAT：1.30)、高甘油三酯血症(OR：1.15；OR：1.56，VAT)和代谢综合征(OR：1.43；OR：1.82，均P<；0.05)有关。腹部脂肪组织衰减每增加5HU，也观察到类似的趋势。即使在进一步考虑了体重指数变化、腰围变化或各自的腹部脂肪组织体积后，大多数相关性仍然显著。除了与泛发性肥胖、中心性肥胖或各自的脂肪组织体积相关外，脂肪量的增加和脂肪衰减的减少与心血管疾病危险因素的恶化有关。
Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) are associated with adverse cardiometabolic risk profiles. This study explored the degree to which changes in abdominal fat quantity and quality are associated with changes in cardiovascular disease (CVD) risk factors. Study participants (n = 1,106; 44.1% women; mean baseline age 45.1 years) were drawn from the Framingham Heart Study Third Generation cohort who participated in the computed tomography (CT) substudy Exams 1 and 2. Participants were followed for 6.1 years on average. Abdominal adipose tissue volume in cm3 and attenuation in Hounsfield units (HU) were determined by CT-acquired abdominal scans. The mean fat volume change was an increase of 602 cm3 for SAT and an increase of 703 cm3 for VAT; the mean fat attenuation change was a decrease of 5.5HU for SAT and an increase of 0.07 HU for VAT. An increase in fat volume and decrease in fat attenuation were associated with adverse changes in CVD risk factors. An additional 500 cm3 increase in fat volume was associated with incident hypertension (odds ratio [OR]: 1.21 for SAT; OR: 1.30 for VAT), hypertriglyceridemia (OR: 1.15 for SAT; OR: 1.56 for VAT), and metabolic syndrome (OR: 1.43 for SAT; OR: 1.82 for VAT; all p < 0.05). Similar trends were observed for each additional 5 HU decrease in abdominal adipose tissue attenuation. Most associations remained significant even after further accounting for body mass index change, waist circumference change, or respective abdominal adipose tissue volumes. Increasing accumulation of fat quantity and decreasing fat attenuation are associated with worsening of CVD risk factors beyond the associations with generalized adiposity, central adiposity, or respective adipose tissue volumes.
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影响因子：
8.3
作者：
Cui, JSS;Hopper, JL;Harrap, SB
通讯作者：
Harrap, SB
影响因子：
16.2
作者：
Matsushita Y;Nakagawa T;Yamamoto S;Takahashi Y;Yokoyama T;Mizoue T;Noda M
通讯作者：
Noda M
影响因子：
37.8
作者：
Abraham TM;Pedley A;Massaro JM;Hoffmann U;Fox CS
通讯作者：
Fox CS
影响因子：
30.8
作者：
Levy, Daniel;Ehret, Georg B.;Rice, Kenneth;Verwoert, Germaine C.;Launer, Lenore J.;Dehghan, Abbas;Glazer, Nicole L.;Morrison, Alanna C.;Johnson, Andrew D.;Aspelund, Thor;Aulchenko, Yurii;Lumley, Thomas;Koettgen, Anna;Vasan, Ramachandran S.;Rivadeneira, Fernando;Eiriksdottir, Gudny;Guo, Xiuqing;Arking, Dan E.;Mitchell, Gary F.;Mattace-Raso, Francesco U. S.;Smith, Albert V.;Taylor, Kent;Scharpf, Robert B.;Hwang, Shih-Jen;Sijbrands, Eric J. G.;Bis, Joshua;Harris, Tamara B.;Ganesh, Santhi K.;O'Donnell, Christopher J.;Hofman, Albert;Rotter, Jerome I.;Coresh, Josef;Benjamin, Emelia J.;Uitterlinden, Andre G.;Heiss, Gerardo;Fox, Caroline S.;Witteman, Jacqueline C. M.;Boerwinkle, Eric;Wang, Thomas J.;Gudnason, Vilmundur;Larson, Martin G.;Chakravarti, Aravinda;Psaty, Bruce M.;van Duijn, Cornelia M.
通讯作者：
van Duijn, Cornelia M.
影响因子：
--
作者：
KANNEL, WB;SORLIE, P
通讯作者：
SORLIE, P