Severity of Anosmia as an Early Symptom of COVID-19 Infection May Predict Lasting Loss of Smell.
Severity of Anosmia as an Early Symptom of COVID-19 Infection May Predict Lasting Loss of Smell.
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DOI：
10.3389/fmed.2020.582802
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发表时间：
2020
影响因子：
3.9
通讯作者：
Saussez S
中科院分区：
文献类型：
--
作者：
Lechien JR;Journe F;Hans S;Chiesa-Estomba CM;Mustin V;Beckers E;Vaira LA;De Riu G;Hopkins C;Saussez S
前言：应用客观嗅觉检测评估新冠肺炎患者嗅觉丧失（LOS）的恢复率。方法：通过蒙斯大学（比利时）的公开招募，前瞻性招募确诊COVID-19和自报突发性LOS的成年人。流行病学和临床数据通过在线患者报告结果问卷收集。患者受益于客观嗅觉评估（嗅嗅棒测试），并被邀请参加反复评估，直到得分恢复到正常水平。结果：2020年3月22日至5月22日，88例突发性LOS患者完成了评估。44.6%的病例出现一般症状后出现LOS。客观评价方面，22例（25.0%）患者在LOS发病后14天内嗅觉恢复。48例（54.5%）患者嗅觉功能在术后第16 ~ 70天恢复。在2个月的最终评估时，20.5%的患者（N = 18）嗅觉功能未达到正常水平。使用嗅探棒测量的嗅觉丧失的基线严重程度较高，可强烈预测持续性丧失（p < 0.001）。结论：术后2个月内，79.5%的患者可预期完全恢复嗅觉功能。嗅觉丧失的严重程度，正如在第一次嗅探棒测试中检测到的那样，可能预示着中期恢复的缺乏。
Introduction: To evaluate the recovery rate of loss of smell (LOS) with objective olfactory testing in COVID-19 patients. Methods: Adults with confirmed COVID-19 and self-reported sudden LOS were prospectively recruited through a public call from the University of Mons (Belgium). Epidemiological and clinical data were collected using online patient-reported outcome questionnaires. Patients benefited from objective olfactory evaluation (Sniffin-Sticks-test) and were invited to attend for repeated evaluation until scores returned to normal levels. Results: From March 22 to May 22, 2020, 88 patients with sudden-onset LOS completed the evaluations. LOS developed after general symptoms in 44.6% of cases. Regarding objective evaluation, 22 patients (25.0%) recovered olfaction within 14 days following the onset of LOS. The smell function recovered between the 16th and the 70th day post-LOS in 48 patients (54.5%). At the time of final assessment at 2 months, 20.5% of patients (N = 18) had not achieved normal levels of olfactory function. Higher baseline severity of olfactory loss measured using Sniffin-Sticks was strongly predictive of persistent loss (p < 0.001). Conclusion: In the first 2 months, 79.5% of patients may expect to have complete recovery of their olfactory function. The severity of olfactory loss, as detected at the first Sniffin-Sticks-test, may predict the lack of mid-term recovery.
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影响因子：
13.6
作者：
通讯作者：
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影响因子：
2.6
作者：
Bhattacharyya, Neil;Kepnes, Lynn J.
通讯作者：
Kepnes, Lynn J.
影响因子：
3.4
作者：
Hopkins, Claire;Surda, Pavol;Kumar, B. Nirmal
通讯作者：
Kumar, B. Nirmal
DOI：
10.1002/hed.26279
发表时间：
2020-05-21
影响因子：
2.9
作者：
Lechien, Jerome R.;Cabaraux, Pierre;Saussez, Sven
通讯作者：
Saussez, Sven
影响因子：
--
作者：
Reden, J;Mueller, A;Hummel, T
通讯作者：
Hummel, T