Sarcopenia: Etiology, Nutritional Approaches, and miRNAs.
Sarcopenia: Etiology, Nutritional Approaches, and miRNAs.
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肌肉减少症：病因，营养方法和miRNA。
DOI：
10.3390/ijms22189724
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发表时间：
2021-09-08
影响因子：
5.6
通讯作者：
Bonilla DA
中科院分区：
文献类型：
--
作者：
Cannataro R;Carbone L;Petro JL;Cione E;Vargas S;Angulo H;Forero DA;Odriozola-Martínez A;Kreider RB;Bonilla DA
肌肉减少症是一种与年龄相关的骨骼肌质量和功能下降，严重影响生活质量。虽然有一个共识，即肌肉减少症是一个多因素综合征，病因和潜在的机制尚未划定。此外，关于预防肌肉减少症的营养干预的研究主要集中在蛋白质摄入量和质量上。考虑到食物摄入时间、抗炎营养素、代谢控制和线粒体功能对肌肉减少症进展的作用的几种营养策略的影响尚未完全了解。本文综述了这种现象的代谢背景，并提出了一种综合营养方法（包括膳食补充剂，如肌酸一水合物），以靶向可能影响减少或改善肌肉减少症的不良反应的潜在分子途径。最后，miRNAs，特别是骨骼肌产生的miRNAs（MyomiR），可能是评估肌肉减少症进展的有效工具，作为诊断和表征的潜在快速和早期生物标志物。
Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial syndrome, the etiology and underlying mechanisms are not yet delineated. Moreover, research about nutritional interventions to prevent the development of sarcopenia is mainly focused on the amount and quality of protein intake. The impact of several nutrition strategies that consider timing of food intake, anti-inflammatory nutrients, metabolic control, and the role of mitochondrial function on the progression of sarcopenia is not fully understood. This narrative review summarizes the metabolic background of this phenomenon and proposes an integral nutritional approach (including dietary supplements such as creatine monohydrate) to target potential molecular pathways that may affect reduce or ameliorate the adverse effects of sarcopenia. Lastly, miRNAs, in particular those produced by skeletal muscle (MyomiR), might represent a valid tool to evaluate sarcopenia progression as a potential rapid and early biomarker for diagnosis and characterization.
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DOI：
10.3390/antiox9100951
发表时间：
2020-10-02
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Barbiera A;Pelosi L;Sica G;Scicchitano BM
通讯作者：
Scicchitano BM
DOI：
10.1177/0884533613507607
发表时间：
2013-12
期刊：
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
影响因子：
--
作者：
Beasley JM;Shikany JM;Thomson CA
通讯作者：
Thomson CA
DOI：
10.1002/jcsm.12232
发表时间：
2017-12
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Brown JL;Rosa-Caldwell ME;Lee DE;Blackwell TA;Brown LA;Perry RA;Haynie WS;Hardee JP;Carson JA;Wiggs MP;Washington TA;Greene NP
通讯作者：
Greene NP
萝卜硫素通过 Nrf2 激活预防心血管疾病。
影响因子：
--
作者：
Bai Y;Wang X;Zhao S;Ma C;Cui J;Zheng Y
通讯作者：
Zheng Y
影响因子：
15.9
作者：
BIOLO, G;FLEMING, RYD;WOLFE, RR
通讯作者：
WOLFE, RR