The role of dietary protein intake in the prevention of sarcopenia of aging.
The role of dietary protein intake in the prevention of sarcopenia of aging.
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DOI：
10.1177/0884533613507607
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Thomson CA
中科院分区：
文献类型：
--
作者：
Beasley JM;Shikany JM;Thomson CA
骨质疏松症被定义为与年龄相关的肌肉质量和表现的下降。对骨质疏松症有几种共识的定义，每种定义都提供了不同的切入点和评估肌肉质量和肌肉力量的方法。因此，据报道，石棺减少的患病率差异很大，通常男性高达45%，女性高达26%。骨质疏松症的危险因素包括年龄、营养不良和缺乏运动。更多证据表明，蛋白质补充剂在老年人中具有保护作用，以保持瘦体重和防止虚弱，这是公认的降低骨质疏松症风险的干预目标。蛋白质补充剂的组成差异很大，而对不同研究设计的小规模试验使其难以推断结果，从而为蛋白质补充剂预防骨质疏松症提供数据驱动、循证的建议。对肌肉蛋白质合成的短期随机对照试验表明，乳清蛋白比酪蛋白或大豆分离蛋白更能促进合成。研究还表明，必需氨基酸比非必需氨基酸更能刺激肌肉蛋白质合成。这篇综述总结了流行病学和临床试验证据，确立了目前对骨质疏松症的定义，并概述了补充蛋白质预防和/或减轻骨质疏松症的证据状况。
Sarcopenia is defined as age-related decrease in muscle mass and performance. Several consensus definitions of sarcopenia exist, each providing different cut points and methodologies for assessing muscle mass and muscle strength. Thus, wide variation in the prevalence of sarcopenia has been reported, generally ranging up to 45% for men and 26% for women. Risk factors for sarcopenia include age, malnutrition, and physical inactivity. Additional evidence suggests a protective role for protein supplementation in older adults in order to preserve lean body mass and prevent frailty, accepted intervention targets for reducing the risk of sarcopenia. Protein supplements vary widely in their composition, and small trials of heterogeneous study designs have made it difficult to extrapolate findings to develop data-driven, evidence-based recommendations for protein supplementation in sarcopenia prevention. Short-term randomized, controlled trials of muscle protein synthesis have demonstrated that whey protein increases synthesis more so than casein or soy isolates. Studies also suggest that essential amino acids stimulate muscle protein synthesis to a greater extent than non-essential amino acids. This review summarizes the epidemiological and clinical trial evidence establishing the current definitions for sarcopenia and provides an overview of the state of the evidence for protein supplementation to prevent and/or mitigate sarcopenia.
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DOI：
10.1016/j.jand.2013.01.014
发表时间：
2013-06-01
影响因子：
4.8
作者：
Berner, Louise A.;Becker, Gabriel;Doi, Jimmy
通讯作者：
Doi, Jimmy
影响因子：
4.2
作者：
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通讯作者：
van Loon, Luc J. C.
影响因子：
2.1
作者：
Barbat-Artigas, Sebastien;Filion, Marie-Eve;Aubertin-Leheudre, Mylene
通讯作者：
Aubertin-Leheudre, Mylene
影响因子：
3.4
作者：
Baier, Shawn;Johannsen, Darcy;Flakoll, Paul
通讯作者：
Flakoll, Paul
影响因子：
6.3
作者：
Batsis, John A.;Barre, Laura K.;Bartels, Stephen J.
通讯作者：
Bartels, Stephen J.