Magnetic resonance imaging determined visceral fat reduction associates with enhanced IL-10 plasma levels in calorie restricted obese subjects.
Magnetic resonance imaging determined visceral fat reduction associates with enhanced IL-10 plasma levels in calorie restricted obese subjects.
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DOI：
10.1371/journal.pone.0052774
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Consoli A
中科院分区：
文献类型：
--
作者：
Formoso G;Taraborrelli M;Guagnano MT;D'Adamo M;Di Pietro N;Tartaro A;Consoli A
肥胖症的特征在于低度慢性炎症状态。事实上，在肥胖受试者中，循环促炎细胞因子（如TNF-α和IL-6）升高，而抗炎细胞因子（如IL-10）似乎降低。细胞因子谱在体重减轻后改善，但内脏或皮下脂肪减少如何分别影响促炎或抗炎细胞因子血浆水平尚未精确评估。因此，在本研究中，我们将循环细胞因子谱的变化与体重减轻前后通过专门的磁共振成像（MRI）方案测量的内脏和皮下脂肪组织贮库的定量变化相关联。在14名肥胖受试者中，在热量限制诱导的体重减轻至少为原始体重的5%之前和之后，进行内脏和皮下脂肪的MRI测定以及血糖、胰岛素、TNF-α、IL-6和IL-10测量。减肥改善胰岛素敏感性（QUICKI指数：0.35±0.03 vs 0.37±0.04; P<0.05），（3.4±1.9 vs 4.6±1.0 pg/mL;血浆TNF-α和IL-6水平分别为2.5± 1.3vs1.6 ± 1.5pg/mL（P<0.0015）和2.3± 0.4vs1.6 ± 0.6pg/mL（P<0.02）。内脏脂肪减少量与TNF-α（r = 0.56，p<0.05）和IL-6（r = 0.19，p<0.05）血浆水平降低百分比之间观察到显著相关性。 在多元回归分析中，内脏脂肪损失量与IL-10血浆水平的增加独立相关。内脏脂肪组织的减少是减肥引起炎症反应改善的主要驱动因素。
Obesity is characterized by a low grade chronic inflammation state. Indeed circulating pro-inflammatory cytokines, such as TNF-α and IL-6, are elevated in obese subjects, while anti-inflammatory cytokines, such as IL-10, appear to be reduced. Cytokines profile improves after weight loss, but how visceral or subcutaneous fat loss respectively affect pro- or anti-inflammatory cytokines plasma levels has not been precisely assessed. Therefore in the present study we correlated changes in circulating cytokine profile with quantitative changes in visceral and subcutaneous adipose tissue depots measured by an ad hoc Magnetic Resonance Imaging (MRI) protocol before and after weight loss. In 14 obese subjects, MRI determination of visceral and subcutaneous fat and plasma glucose, insulin, TNF-α IL-6, and IL-10 measurements were performed before and after a caloric restriction induced weight loss of at least 5% of the original body weight. Weight loss improved insulin sensitivity (QUICKI Index: 0.35±0.03 vs 0.37±0.04; P<0.05), increased IL-10 (3.4±1.9 vs 4.6±1.0 pg/mL; P<0.03), and reduced TNF-α and IL-6 plasma levels (2.5±1.3 vs 1.6±1.5 pg/mL, P<0.0015, 2.3±0.4 vs 1.6±0.6 pg/mL, P<0.02 respectively). A significant correlation was observed between the amount of visceral fat loss and the percentage reduction in both TNF-α (r = 0.56, p<0.05) and IL-6 (r = 0.19 p<0.05) plasma levels. In a multiple regression analysis, the amount of visceral fat loss independently correlated with the increase in IL-10 plasma levels. The reduction in visceral adipose tissue is the main driver of the improved inflammatory profile induced by weight loss.
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影响因子：
4.8
作者：
Fain, JN;Madan, AK;Bahouth, SW
通讯作者：
Bahouth, SW
DOI：
10.1038/oby.2010.248
发表时间：
2011-02
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
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