Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry.
Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry.
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DOI：
10.3389/fphys.2018.01248
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发表时间：
2018
影响因子：
4
通讯作者：
Huizinga JD
中科院分区：
文献类型：
--
作者：
Chen JH;Parsons SP;Shokrollahi M;Wan A;Vincent AD;Yuan Y;Pervez M;Chen WL;Xue M;Zhang KK;Eshtiaghi A;Armstrong D;Bercik P;Moayyedi P;Greenwald E;Ratcliffe EM;Huizinga JD
同时压力波（SPW）在人体结肠测压记录已与气体排出。我们的假设是SPW可能是大多数结肠运动功能的关键组成部分，因此可能作为健康结肠运动的生物标志物。为此，我们在17名健康志愿者中首次使用84传感器（间距1 cm）水灌注导管进行高分辨率结肠测压（HRCM）。在基线、近端和直肠球囊扩张期间、餐后以及近端和直肠腔内比沙可啶给药后记录腔内压力模式。使用本研究期间开发的基于Image J的软件进行定量。气体排出总是与SPW相关，此外，SPW与水或气球排出相关。SPWs显着出现在近端高振幅传播压力波（HAPWs）的终止，我们称之为这种电机模式HAPW-SPWs，因此，SPWs往往不是一个泛结肠事件。基线时观察到SPW和HAPW-SPW，SPW振幅分别为12.0 ± 8.5 mmHg和20.2 ± 7.2 mmHg。SPW的发生率和幅度在进餐、球囊扩张和管腔比沙可啶后显著增加，与基线时50.3%的肛门括约肌松弛相关，进餐后显著增加至59.0%，比沙可啶后显著增加至69.1%。通常情况下，完全放松。与气体排出相关联的SPW与没有气体排出的SPW相比具有显著更高的振幅。可以看到SPW由高频压力波簇组成，可能与快速传播的环形肌肉收缩簇相关。SPW偶尔以1.8 ± 1.2周期/分钟的高度节律模式观察到。与HAPW不同，SPW没有消除吸器边界，从而解释了气体如何被排出，而固体含量仍然受到吸器边界的限制。因此，SPW可能成为正常气体传输、胃结肠反射和外源性神经反射的生物标志物。SPW评估揭示了结肠、直肠和肛门括约肌活动的协调。SPW可能成为结肠动力障碍患者的诊断价值。
Simultaneous pressure waves (SPWs) in manometry recordings of the human colon have been associated with gas expulsion. Our hypothesis was that the SPW might be a critical component of most colonic motor functions, and hence might act as a biomarker for healthy colon motility. To that end, we performed high-resolution colonic manometry (HRCM), for the first time using an 84-sensor (1 cm spaced) water-perfused catheter, in 17 healthy volunteers. Intraluminal pressure patterns were recorded during baseline, proximal and rectal balloon distention, after a meal and following proximal and rectal luminal bisacodyl administration. Quantification was performed using software, based on Image J, developed during this study. Gas expulsion was always associated with SPWs, furthermore, SPWs were associated with water or balloon expulsion. SPWs were prominently emerging at the termination of proximal high amplitude propagating pressure waves (HAPWs); we termed this motor pattern HAPW-SPWs; hence, SPWs were often not a pan-colonic event. SPWs and HAPW-SPWs were observed at baseline with SPW amplitudes of 12.0 ± 8.5 mmHg and 20.2 ± 7.2 mmHg respectively. The SPW occurrence and amplitude significantly increased in response to meal, balloon distention and luminal bisacodyl, associated with 50.3% anal sphincter relaxation at baseline, which significantly increased to 59.0% after a meal, and 69.1% after bisacodyl. Often, full relaxation was achieved. The SPWs associated with gas expulsion had a significantly higher amplitude compared to SPWs without gas expulsion. SPWs could be seen to consist of clusters of high frequency pressure waves, likely associated with a cluster of fast propagating, circular muscle contractions. SPWs were occasionally observed in a highly rhythmic pattern at 1.8 ± 1.2 cycles/min. Unlike HAPWs, the SPWs did not obliterate haustral boundaries thereby explaining how gas can be expelled while solid content can remain restrained by the haustral boundaries. In conclusion, the SPW may become a biomarker for normal gas transit, the gastrocolonic reflex and extrinsic neural reflexes. The SPW assessment reveals coordination of activities in the colon, rectum and anal sphincters. SPWs may become of diagnostic value in patients with colonic dysmotility.
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影响因子：
29.4
作者：
Brierley, SM;Jones, RCW;Blackshaw, LA
通讯作者：
Blackshaw, LA
影响因子：
3.9
作者：
Broens, Paul M. A.;Penninckx, Freddy M.;Boix Ochoa, Jose
通讯作者：
Boix Ochoa, Jose
影响因子：
3.1
作者：
De Schryver, AMP;Samsom, M;Smout, AIPM
通讯作者：
Smout, AIPM
影响因子：
3.5
作者：
Dinning, P. G.;Wiklendt, L.;Arkwright, J. W.
通讯作者：
Arkwright, J. W.
影响因子：
24.5
作者：
de Lorijn, F;de Jonge, WJ;Boeckxstaens, GE
通讯作者：
Boeckxstaens, GE