The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.
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DOI：
10.1016/j.neuron.2017.07.030
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发表时间：
2017-09-27
期刊：
影响因子：
16.2
通讯作者：
Iadecola C
中科院分区：
文献类型：
--
作者：
Iadecola C
神经血管单位（NVU）的概念，在2001年国家神经疾病和中风研究所中风进展审查小组会议上正式确定，强调大脑与其血管之间的密切关系。从那时起，NVU吸引了神经科学界的兴趣，导致该领域取得了相当大的进展。在这里，将评估NVU的当前知识状态，重点关注其最重要的作用之一：神经活动和血流之间的耦合。证据支持神经血管耦合机制的概念转变，从涉及神经元-星形胶质细胞信号传导到局部血管的一维过程，到从多个细胞释放的介质以高度协调的方式参与整个脑血管网络的不同信号通路和效应系统的多维过程。最近认识到的神经退行性疾病中的NVU功能障碍，虽然仍然知之甚少，但支持维持神经血管健康促进大脑健康的新兴概念。
The concept of neurovascular unit (NVU), formalized at the 2001 Stroke Progress Review Group meeting of the National Institute of Neurological Disorders and Stroke, emphasizes the intimate relationship between the brain and its vessels. Since then, the NVU has attracted the interest of the neuroscience community resulting in considerable advances in the field. Here the current state-of-knowledge of the NVU will be assessed, focusing on one of its most vital roles: the coupling between neural activity and blood flow. The evidence supports a conceptual shift in the mechanisms of neurovascular coupling, from a unidimensional process involving neuronal-astrocytic signaling to local blood vessels, to a multidimensional one in which mediators released from multiple cells engage distinct signaling pathways and effector systems across the entire cerebrovascular network in a highly orchestrated manner. The recently appreciated NVU dysfunction in neurodegenerative diseases, although still poorly understood, supports emerging concepts that maintaining neurovascular health promotes brain health.
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影响因子：
6.3
作者：
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通讯作者：
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DOI：
10.1111/j.1748-1716.1976.tb10176.x
发表时间：
1976-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
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影响因子：
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