Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins.
Evidence for shared genetic influences on self-reported ADHD and autistic symptoms in young adult Australian twins.
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DOI：
10.1375/twin.11.6.579
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Todd RD
中科院分区：
文献类型：
--
作者：
Reiersen AM;Constantino JN;Grimmer M;Martin NG;Todd RD
最近基于临床和基于人群的研究表明，儿童和青少年多动症和自闭症症状之间存在关联，这些疾病之间也存在遗传重叠的证据。本研究的目的是确认自闭症和ADHD症状之间的联系，在一个年轻的双胞胎样本中，通过自我报告评估，并调查共同的遗传和/或环境因素是否可以解释这种联系。我们使用来自674名澳大利亚年轻成年双胞胎的11个社会反应性量表（SRS）项目和12个DSM-IV ADHD注意力不集中和冲动症状项目的自我报告数据进行了基于双胞胎的结构方程建模。自闭症与ADHD症状的表型相关性为中度。SRS和ADHD最简洁的单变量模型包括加性遗传效应和独特的环境效应，没有性别差异。多动症和自闭症的特征都有中等程度的遗传性。在双变量模型中，SRS与ADHD的遗传相关（rg）为0.72。我们的研究结果表明，在年轻人中，自我报告的自闭症和多动症症状的很大一部分遗传影响可能在这两种疾病之间共享。
Recent clinic-based and population-based studies have shown evidence of association between ADHD and autistic symptoms in children and adolescents as well as evidence for genetic overlap between these disorders. The objective of the current study was to confirm the association between autistic and ADHD symptoms in a young adult twin sample assessed by self-report, and investigate whether shared genetic and/or environmental factors can explain the association. We performed twin-based structural equation modeling using self-report data from 11 Social Responsiveness Scale (SRS) items and 12 DSM-IV ADHD inattentive and impulsive symptom items obtained from 674 young adult Australian twins. Phenotypic correlation between autistic and ADHD symptoms was moderate. The most parsimonious univariate models for SRS and ADHD included additive genetic effects and unique environmental effects, without sex differences. ADHD and autistic traits were both moderately heritable. In a bivariate model, genetic correlation (rg) between SRS and ADHD was 0.72. Our results suggest that in young adults, a substantial proportion of the genetic influences on self-reported autistic and ADHD symptoms may be shared between the two disorders.
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DOI：
10.1097/01.chi.0000046811.95464.21
发表时间：
2003-04-01
影响因子：
13.3
作者：
Constantino, JN;Hudziak, JJ;Todd, RD
通讯作者：
Todd, RD
DOI：
10.1111/j.1469-7610.2007.01857.x
发表时间：
2008-05-01
影响因子：
7.6
作者：
Ronald, Angelica;Simonoff, Emily;Plomin, Robert
通讯作者：
Plomin, Robert
影响因子：
6.4
作者：
Santosh, PJ;Mijovic, A
通讯作者：
Mijovic, A
DOI：
10.1002/ajmg.b.30640
发表时间：
2007-12-05
影响因子：
2.8
作者：
Todd, Richard D.;Neuman, Rosalind J.
通讯作者：
Neuman, Rosalind J.
影响因子：
1.9
作者：
MARTIN, NG;MARTIN, PG
通讯作者：
MARTIN, PG