White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study.
White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study.
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DOI：
10.1371/journal.pone.0246304
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Arima H
中科院分区：
文献类型：
--
作者：
Ishida S;Kondo S;Funakoshi S;Satoh A;Maeda T;Kawazoe M;Yoshimura C;Tada K;Takahashi K;Ito K;Yasuno T;Masutani K;Nakashima H;Arima H
本研究旨在阐明日本普通人群中白细胞(WBC)计数与高血压的关系。我们利用日本长崎县Iki市居民的年度健康检查数据进行了一项以人群为基础的回顾性队列研究。本研究共纳入2935名基线无高血压的受试者。白细胞计数分为三级(4 700/μL)、三级(4 700-5 999/μL)和三级(≥6 0 0 0/μL)。结果是偶发高血压(血压≥140毫米汞柱)。多变量调整后的危险比和95%可信区间(95%CI)用COX比例风险模型估计。在平均4.5年的随访中，908名参与者患上了高血压。高血压的发病率(每100人年)随着WBC计数的增加而增加(三分位数1为6.3，四分位数2为7.0，三分位数为7.4)。即使在调整了年龄、性别、当前吸烟习惯、当前酒精摄入量、运动习惯、肥胖、高血压、糖尿病和血脂异常等其他危险因素后，这种关联也是显著的。与四元组1相比，四元组2和3的风险比分别为1.07(95%可信区间0.90~1.26)和1.27(95%可信区间1.06~1.51)(p=0.009)。在日本普通人群中，白细胞计数与高血压的未来发展有关。
This study aimed to clarify the relationship between the white blood cell (WBC) count and hypertension in the general Japanese population. We conducted a population-based retrospective cohort study using annual health check-up data of residents of Iki City, Nagasaki Prefecture, Japan. A total of 2935 participants without hypertension at baseline were included in the present analysis. WBC counts were classified as tertile 1 (<4700/μL), tertile 2 (4700–5999/μL), and tertile 3 (≥6000/μL). The outcome was incident hypertension (blood pressure ≥140 mmHg). Multivariable-adjusted hazard ratios and 95% confidence intervals (95% CIs) were estimated using the Cox proportional hazards model. During an average follow-up of 4.5 years, 908 participants developed hypertension. The incidence (per 100 person-years) of hypertension increased with an elevation in the WBC count (6.3 in tertile 1, 7.0 in tertile 2, and 7.4 in tertile 3). This association was significant, even after adjustment for other risk factors, including age, sex, current smoking habits, current alcohol intake, exercise habits, obesity, elevated blood pressure, diabetes mellitus, and dyslipidemia. The hazard ratios were 1.07 for tertile 2 (95% CI 0.90–1.26) and 1.27 for tertile 3 (95% CI 1.06–1.51) compared with the reference group of tertile 1 (p = 0.009). The WBC count was associated with future development of hypertension in the general Japanese population.
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影响因子：
4.9
作者：
Nakanishi, N;Sato, M;Tatara, K
通讯作者：
Tatara, K
影响因子：
5.4
作者：
Tatsukawa, Yoshimi;Hsu, Wan-Ling;Kohno, Nobuoki
通讯作者：
Kohno, Nobuoki
DOI：
10.1097/gme.0000000000000609
发表时间：
2016-06-01
期刊：
MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY
影响因子：
--
作者：
Ebong, Imo A.;Schreiner, Pamela;Wellons, Mellissa
通讯作者：
Wellons, Mellissa
影响因子：
3.3
作者：
Matsuzawa, Y;Nakamura, T;Nagai, M
通讯作者：
Nagai, M
影响因子：
2.8
作者：
Wang, Huan;Hu, Yuanhui;Qiu, Zhiling
通讯作者：
Qiu, Zhiling