Effects of developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats.
Effects of developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats.
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DOI：
10.1289/ehp.8391
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发表时间：
2006-02
影响因子：
10.4
通讯作者：
Talsness CE
中科院分区：
文献类型：
--
作者：
Lilienthal H;Hack A;Roth-Härer A;Grande SW;Talsness CE
母乳中多溴化阻燃剂（包括多溴联苯醚）的浓度不断增加，这引起了人们对哺乳婴儿可能的发育影响的担忧。由于先前的研究表明，大鼠性类固醇和性二态行为的影响后，母体暴露于多氯联苯（PCB），我们在本研究中的目标是确定是否发育暴露于2，2 ′，4，4 ′，5-五溴二苯醚（PBDE-99）诱导类似的内分泌介导的影响。使怀孕大鼠接触溶剂或PBDE-99（1或10毫克/千克体重，妊娠第10-18天每天）。为了进行比较，我们还包括一组暴露于技术PCB混合物Aroclor 1254（30 mg/kg体重，每日）。接触多溴二苯醚会导致雄性后代在断奶和成年时体内循环的性类固醇显著减少。雌性后代受影响较小。雄性后代的肛门生殖器距离减少。在较高剂量水平下，雌性后代的青春期开始延迟，而在低剂量雄性中检测到轻微加速。在较低剂量下，雌性动物的原始/初级卵泡数量减少，而在较高剂量下，次级卵泡的减少更为明显。在接触多溴二苯醚的成年男性中，甜食偏好呈剂量依赖性增加，这表明这种两性异形行为的女性化。Aroclor 1254不会改变甜味偏好和原始/初级和次级卵泡的数量，但会影响雄性的类固醇浓度和两性的性发育。母体和后代组织中的多溴二苯醚浓度在妊娠第19天最高。这些结果支持了多溴二苯醚是内分泌活性化合物并干扰性发育和两性行为的假设。
Increasing concentrations of polybrominated flame retardants, including polybrominated diphenyl ethers (PBDEs), in breast milk cause concern about possible developmental effects in nursed babies. Because previous studies in rats have indicated effects on sex steroids and sexually dimorphic behavior after maternal exposure to polychlorinated biphenyls (PCBs), our goal in the present study was to determine if developmental exposure to 2,2′,4,4′,5-pentabromodiphenyl ether (PBDE-99) induces similar endocrine-mediated effects. Pregnant rats were exposed to vehicle or PBDE-99 (1 or 10 mg/kg body weight, daily during gestational days 10–18). For comparison, we also included a group exposed to the technical PCB mixture Aroclor 1254 (30 mg/kg body weight, daily). PBDE exposure resulted in pronounced decreases in circulating sex steroids in male offspring at weaning and in adulthood. Female offspring were less affected. Anogenital distance was reduced in male offspring. Puberty onset was delayed in female offspring at the higher dose level, whereas a slight acceleration was detected in low-dose males. The number of primordial/primary ovarian follicles was reduced in females at the lower dose, whereas decline of secondary follicles was more pronounced at the higher dose. Sweet preference was dose-dependently increased in PBDE-exposed adult males, indicating a feminization of this sexually dimorphic behavior. Aroclor 1254 did not alter sweet preference and numbers of primordial/primary and secondary follicles but it did affect steroid concentrations in males and sexual development in both sexes. PBDE concentrations in tissues of dams and offspring were highest on gestational day 19. These results support the hypothesis that PBDEs are endocrine-active compounds and interfere with sexual development and sexually dimorphic behavior.
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影响因子：
4.3
作者：
Eriksson, P;Fredriksson, A
通讯作者：
Fredriksson, A
影响因子：
--
作者：
CHAN, WY;NG, TB
通讯作者：
NG, TB
影响因子：
10.4
作者：
Kuriyama SN;Talsness CE;Grote K;Chahoud I
通讯作者：
Chahoud I
影响因子：
3.3
作者：
Lyche, JL;Oskam, IC;Ropstad, E
通讯作者：
Ropstad, E
影响因子：
3.7
作者：
Gore, AC
通讯作者：
Gore, AC