Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring.
Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspring.
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DOI：
10.1289/ehp.7421
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发表时间：
2005-02
影响因子：
10.4
通讯作者：
Chahoud I
中科院分区：
文献类型：
--
作者：
Kuriyama SN;Talsness CE;Grote K;Chahoud I
在子宫内暴露于单一低剂量的2，2 ′，4，4 ′，5-五溴二苯醚（PBDE-99）会破坏神经行为发育，并对成年雄性大鼠生殖系统造成明显的永久性影响。PBDEs是一类阻燃剂，广泛用于现代生活的各个部门以防止火灾。它们在环境中具有持久性，在生物群和母乳中发现多溴二苯醚的含量不断增加。在本研究中，我们评估了发育暴露于最持久的多溴联苯醚同系物（PBDE-99）对青少年基础运动活动水平和成年男性生殖健康的影响。Wistar大鼠母鼠在妊娠第6天被灌胃给予60或300微克PBDE-99/千克体重的单一低剂量。在后代中，在出生后第36天和第71天评价基础运动活动，并在成年时评估雄性的生殖性能。在发育过程中暴露于低剂量的PBDE-99会导致后代在两个时间点都表现出过度活跃，并通过减少精子和精子细胞数量永久性地损害精子生成。本研究中使用的剂量（60和300微克/千克体重）与人体接触水平有关，分别比报告的人类乳房脂肪组织中的最高水平高出约6倍和29倍。这是迄今为止报告的多溴二苯醚在啮齿动物体内产生毒性效应的最低剂量，支持了应鼓励开展低剂量研究以确定持久性环境污染物危害的假设。
In utero exposure to a single low dose of 2,2′,4,4′,5-pentabromodiphenyl ether (PBDE-99) disrupts neurobehavioral development and causes permanent effects on the rat male reproductive system apparent in adulthood. PBDEs, a class of flame retardants, are widely used in every sector of modern life to prevent fire. They are persistent in the environment, and increasing levels of PBDEs have been found in biota and human breast milk. In the present study we assessed the effects of developmental exposure to one of the most persistent PBDE congeners (PBDE-99) on juvenile basal motor activity levels and adult male reproductive health. Wistar rat dams were treated by gavage on gestation day 6 with a single low dose of 60 or 300 μg PBDE-99/kg body weight (bw). In offspring, basal locomotor activity was evaluated on postnatal days 36 and 71, and reproductive performance was assessed in males at adulthood. The exposure to low-dose PBDE-99 during development caused hyperactivity in the offspring at both time points and permanently impaired spermatogenesis by the means of reduced sperm and spermatid counts. The doses used in this study (60 and 300 μg/kg bw) are relevant to human exposure levels, being approximately 6 and 29 times, respectively, higher than the highest level reported in human breast adipose tissue. This is the lowest dose of PBDE reported to date to have an in vivo toxic effect in rodents and supports the premise that low-dose studies should be encouraged for hazard identification of persistent environmental pollutants.
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影响因子：
3.3
作者：
Chahoud, I;Faqi, AS
通讯作者：
Faqi, AS
影响因子：
2.2
作者：
DAVENPORT, JW;HENNIES, RS
通讯作者：
HENNIES, RS
影响因子：
6.6
作者：
CZEIZEL, A;ERODI, E;TOTH, J
通讯作者：
TOTH, J
影响因子：
105.7
作者：
Irvine, S;Cawood, E;Aitken, J
通讯作者：
Aitken, J
DOI：
10.1016/0277-5379(87)90286-0
发表时间：
1987-06-01
期刊：
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY
影响因子：
--
作者：
BOYLE, P;KAYE, SB;ROBERTSON, AG
通讯作者：
ROBERTSON, AG