Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm.
Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm.
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DOI：
10.1111/imr.12120
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发表时间：
2013-11
影响因子：
8.7
通讯作者：
Krummel MF
中科院分区：
文献类型：
--
作者：
Beemiller P;Krummel MF
The actin cytoskeleton plays essential roles in modulating T-cell activation. Most models of T-cell receptor (TCR) triggering, signalosome assembl, y and immune synapse formation invoke actin-dependent mechanisms. As T cells are constitutively motile cells, TCR triggering and signaling occur against a cytoskeletal backdrop that is constantly remodeling. While the interplay between actin dynamics and TCR signaling have been the focus of research for many years, much of the work in T cells has considered actin largely for its ‘scaffolding’ function. We examine the roles of the actin cytoskeleton in TCR signaling and immune synapse formation with an emphasis on how poroelasticity, an ensemble feature of actin dynamics with the cytosol, relates to how T cells respond to stimulation.
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影响因子：
5.4
作者：
Brossard, C;Feuillet, V;Trautmann, A
通讯作者：
Trautmann, A
影响因子：
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作者：
DeMond, Andrew L.;Mossman, Kaspar D.;Groves, Jay T.
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Groves, Jay T.
DOI：
10.1083/jcb.201201018
发表时间：
2012-06-11
期刊：
The Journal of cell biology
影响因子：
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Burkhardt JK
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作者：
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van der Merwe, P. Anton
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32.4
作者：
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Valitutti, S