Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.
Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.
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DOI：
10.1016/j.ebiom.2021.103445
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发表时间：
2021-07
期刊：
影响因子：
11.1
通讯作者：
van der Wee NJA
中科院分区：
文献类型：
--
作者：
Bas-Hoogendam JM;van Steenbergen H;Cohen Kadosh K;Westenberg PM;van der Wee NJA
社交焦虑障碍（Social anxiety disorder， SAD）是一种严重的精神疾病，发病率高，通常发生在儿童/青少年时期。这种情况在家族中存在，但在很大程度上尚不清楚是哪种神经生物学特征转移了这种遗传脆弱性（“内表型”）。利用来自莱顿家庭实验室关于SAD的研究数据，包括两代遗传丰富的SAD家庭，我们研究了社交焦虑（SA）是否与内在功能连接（iFC）的变化共分离，并检验了遗传力。在静息状态下获得109例患者（56例男性，平均年龄31.5岁，范围9.2 ~ 61.5岁）的功能MRI数据。使用FSL的MELODIC工具进行独立成分分析。六个兴趣网络（默认模式、背侧注意、执行控制、额顶叶、边缘和显著性）在群体水平上被识别出来，并用于生成特定受试者的空间地图。采用体素回归模型，以SA水平为预测因子，以体素iFC为候选内表型，在感兴趣的网络掩膜内研究与SA的关联。随后，对遗传力进行了估计。SA与iFC在背侧注意网络（左侧额中回和右侧中央后回正相关）和额顶叶网络（左侧颞中回正相关）内共分离（簇形成-阈值z bbb2.0，簇校正范围-阈值p< 0.05）。此外，这些簇内多个体素的iFC至少具有中等程度的可遗传性。这些发现为iFC增加作为SAD的候选内表型提供了初步证据，特别是在涉及注意力的网络中。这些变化可能是SAD中常见的注意偏差的基础。莱顿大学研究概况“健康、预防和人类生命周期”。
Social anxiety disorder (SAD) is a serious psychiatric condition with a high prevalence, and a typical onset during childhood/adolescence. The condition runs in families, but it is largely unknown which neurobiological characteristics transfer this genetic vulnerability (‘endophenotypes’). Using data from the Leiden Family Lab study on SAD, including two generations of families genetically enriched for SAD, we investigated whether social anxiety (SA) co-segregated with changes in intrinsic functional connectivity (iFC), and examined heritability. Functional MRI data were acquired during resting-state in 109 individuals (56 males; mean age: 31·5, range 9·2-61·5 years). FSL's tool MELODIC was used to perform independent component analysis. Six networks of interest (default mode, dorsal attention, executive control, frontoparietal, limbic and salience) were identified at the group-level and used to generate subject-specific spatial maps. Voxel-wise regression models, with SA-level as predictor and voxel-wise iFC as candidate endophenotypes, were performed to investigate the association with SA, within masks of the networks of interest. Subsequently, heritability was estimated. SA co-segregated with iFC within the dorsal attention network (positive association in left middle frontal gyrus and right postcentral gyrus) and frontoparietal network (positive association within left middle temporal gyrus) (cluster-forming-threshold z>2·3, cluster-corrected extent-threshold p<0·05). Furthermore, iFC of multiple voxels within these clusters was at least moderately heritable. These findings provide initial evidence for increased iFC as candidate endophenotype of SAD, particularly within networks involved in attention. These changes might underlie attentional biases commonly present in SAD. Leiden University Research Profile ‘Health, Prevention and the Human Lifecycle’.
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影响因子：
7.4
作者：
Alonso J;Liu Z;Evans-Lacko S;Sadikova E;Sampson N;Chatterji S;Abdulmalik J;Aguilar-Gaxiola S;Al-Hamzawi A;Andrade LH;Bruffaerts R;Cardoso G;Cia A;Florescu S;de Girolamo G;Gureje O;Haro JM;He Y;de Jonge P;Karam EG;Kawakami N;Kovess-Masfety V;Lee S;Levinson D;Medina-Mora ME;Navarro-Mateu F;Pennell BE;Piazza M;Posada-Villa J;Ten Have M;Zarkov Z;Kessler RC;Thornicroft G;WHO World Mental Health Survey Collaborators
通讯作者：
WHO World Mental Health Survey Collaborators
影响因子：
4.2
作者：
Bas-Hoogendam, Janna Marie;van Steenbergen, Henk;van der Wee, Nic J. A.
通讯作者：
van der Wee, Nic J. A.
影响因子：
3.1
作者：
Bandelow, Borwin;Baldwin, David;Riederer, Peter
通讯作者：
Riederer, Peter
影响因子：
7.4
作者：
Bas-Hoogendam, Janna M.;van Steenbergen, Henk;Westenberg, P. Michiel
通讯作者：
Westenberg, P. Michiel
影响因子：
11.1
作者：
Bas-Hoogendam JM;van Steenbergen H;Tissier RLM;Houwing-Duistermaat JJ;Westenberg PM;van der Wee NJA
通讯作者：
van der Wee NJA