"Brain MR spectroscopy in autism spectrum disorder-the GABA excitatory/inhibitory imbalance theory revisited".
"Brain MR spectroscopy in autism spectrum disorder-the GABA excitatory/inhibitory imbalance theory revisited".
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DOI：
10.3389/fnhum.2015.00365
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发表时间：
2015
影响因子：
2.9
通讯作者：
Beyer MK
中科院分区：
文献类型：
--
作者：
Brix MK;Ersland L;Hugdahl K;Grüner R;Posserud MB;Hammar Å;Craven AR;Noeske R;Evans CJ;Walker HB;Midtvedt T;Beyer MK
对14例孤独症谱系障碍（ASD）患儿和24例正常对照组儿童的左前扣带皮层（ACC）进行磁共振波谱（MRS）检测。我们的主要目的是比较两组之间的γ-氨基丁酸（GABA）的浓度，并探讨ASD组中大脑代谢产物与自闭症症状严重程度的关系。我们确实发现ASD组中自闭症谱系筛查问卷（ASSQ）和GABA+/Cr之间存在显著的负相关性，这可能意味着ASD症状的严重程度与大脑中GABA水平的差异有关，支持兴奋/抑制（E/I）失衡理论。然而，我们没有发现两组之间的GABA水平的显着差异。
Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex (ACC) was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.
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影响因子：
4.9
作者：
Gogolla, Nadine;LeBlanc, Jocelyn J.;Quast, Kathleen B.;Sudhof, Thomas C.;Fagiolini, Michela;Hensch, Takao K.
通讯作者：
Hensch, Takao K.
影响因子：
3.9
作者：
Cornew, Lauren;Roberts, Timothy P. L.;Blaskey, Lisa;Edgar, J. Christopher
通讯作者：
Edgar, J. Christopher
影响因子：
1.7
作者：
Grice, SJ;Spratling, MW;Johnson, MH
通讯作者：
Johnson, MH
影响因子：
1.9
作者：
Cochran, David M.;Sikoglu, Elif M.;Frazier, Jean A.
通讯作者：
Frazier, Jean A.
影响因子：
10.5
作者：
Baron-Cohen, Simon;Scott, Fiona J.;Brayne, Carol
通讯作者：
Brayne, Carol