KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis.
KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis.
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DOI：
10.4142/jvs.2017.18.4.487
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发表时间：
2017-12-31
影响因子：
1.8
通讯作者：
Kang KS
中科院分区：
文献类型：
--
作者：
Kook MG;Choi SW;Seo Y;Kim DW;Song BK;Son I;Kim S;Kang KS
肌萎缩侧索硬化症是一种以中枢神经系统运动神经元选择性死亡为特征的神经退行性疾病。这种疾病的主要原因仍然不清楚，但已经有几个突变与疾病过程有关。特别是，突变的超氧化物歧化酶1(SOD1)蛋白通过激活胶质细胞引起氧化应激，并导致运动神经元退化。KCHO-1是一种新型草药组合化合物，含有30%的乙醇和九种草药的提取物，这些草药通常用于防止疲劳或炎症。在这项研究中，我们研究了Kcho-1给药是否可以减轻ALS模型中的氧化应激。给ALS模型小鼠注射KCHO-1改善了运动功能，推迟了疾病的发生。此外，Kcho-1通过gp91Phox和MAPK通路减少了hSOD1G93A转基因小鼠经典激活的小胶质细胞和脊髓中的氧化应激。结果表明，KCHO-1可通过降低氧化应激而作为ALS的有效治疗剂。
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons in the central nervous system. The main cause of the disease remains elusive, but several mutations have been associated with the disease process. In particular, mutant superoxide dismutase 1 (SOD1) protein causes oxidative stress by activating glia cells and contributes to motor neuron degeneration. KCHO-1, a novel herbal combination compound, contains 30% ethanol and the extracts of nine herbs that have been commonly used in traditional medicine to prevent fatigue or inflammation. In this study, we investigated whether KCHO-1 administration could reduce oxidative stress in an ALS model. KCHO-1 administered to ALS model mice improved motor function and delayed disease onset. Furthermore, KCHO-1 administration reduced oxidative stress through gp91phox and the MAPK pathway in both classically activated microglia and the spinal cord of hSOD1G93A transgenic mice. The results suggest that KCHO-1 can function as an effective therapeutic agent for ALS by reducing oxidative stress.
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影响因子：
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作者：
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