Association between neovascular age-related macular degeneration and dementia: a population-based case-control study in Taiwan.
Association between neovascular age-related macular degeneration and dementia: a population-based case-control study in Taiwan.
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DOI：
10.1371/journal.pone.0120003
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Sheu JJ
中科院分区：
文献类型：
--
作者：
Chung SD;Lee CZ;Kao LT;Lin HC;Tsai MC;Sheu JJ
大多数现有的研究集中在新生血管性年龄相关性黄斑变性（AMD）和痴呆之间的关系，结果相互矛盾。本研究旨在调查先前诊断的AMD与痴呆之间的关系，使用基于台湾人群的数据集。本病例对照研究的资料回溯性收集自台湾全民健康保险研究数据库。我们确定了13402名被诊断为痴呆症的受试者作为病例，40206名未被诊断为痴呆症的受试者作为对照。使用条件逻辑回归来检查痴呆与先前诊断的新血管性AMD的关系。我们发现，在53,608名受试者的研究样本中，1.01%先前诊断为新生血管性AMD，病例和对照组分别为1.35%和0.90% （p<0.001）。条件logistic回归分析显示，在调整受试者年龄、月收入、地理位置、城市化水平、高脂血症、糖尿病、高血压、中风、缺血性心脏病以及受试者在指数日期前是否接受过白内障手术等因素后，与对照组相比，既往新生血管性AMD病例的比值比为1.37（95%可信区间：1.14~1.65）。与对照组相比，痴呆患者先前发生血管性AMD的比例更高。
Most available studies focusing on the association between neovascular age-related macular degeneration (AMD) and dementia have conflicting results. This study aimed to investigate the association between previously diagnosed AMD and dementia using a population-based dataset in Taiwan. Data for this case-control study were retrospectively collected from the Taiwan National Health Insurance Research Database. We identified 13,402 subjects who had a diagnosis of dementia as cases, and 40,206 subjects without dementia as controls. A conditional logistic regression was used to examine the association of dementia with previously diagnosed neovascular AMD. We found that of the study sample of 53,608 subjects, 1.01% had previously diagnosed neovascular AMD, 1.35% and 0.90% for cases and the controls, respectively (p<0.001). The conditional logistic regression analysis suggested that the odds ratio of prior neovascular AMD for cases was 1.37 (95% confidence interval: 1.14~1.65) compared to the controls after adjusting for subjects’ age, monthly income, geographic location, urbanization level, and hyperlipidemia, diabetes, hypertension, stroke, ischemic heart disease, and whether or not a subjects underwent cataract surgery prior to index date than controls. Dementia subjects were associated with a higher proportion of prior neovascular AMD than were the controls.
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DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
48
作者：
Kalaria, Raj N.;Maestre, Gladys E.;Arizaga, Raul;Friedland, Robert P.;Galasko, Doug;Hall, Kathleen;Luchsinger, Jose A.;Ogunniyi, Adesola;Perry, Elaine K.;Potocnik, Felix;Prince, Martin;Stewart, Robert;Wimo, Anders;Zhang, Zhen-Xin;Antuono, Piero
通讯作者：
Antuono, Piero
影响因子：
158.5
作者：
Verghese, J;Lipton, RB;Buschke, H
通讯作者：
Buschke, H
影响因子：
8.3
作者：
Gorelick, PB
通讯作者：
Gorelick, PB
影响因子：
13.7
作者：
Klein, R;Klein, BEK;Jacobs, DR
通讯作者：
Jacobs, DR