Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions.
Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions.
复制标题
大鼠和小鼠的行为灵活性：不同额叶区域的贡献。
DOI：
10.1111/gbb.12191
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Brigman JL
中科院分区：
文献类型：
--
作者：
Hamilton DA;Brigman JL
研究遗传学对行为的贡献越来越多地集中在更高层次的行为和认知过程，包括当环境需求改变时改变行为的能力。哺乳动物（包括啮齿动物）的额叶皮质有助于各种行为和认知功能，包括运动规划、社会行为、预期结果的评估和工作记忆，这些功能可能对遗传因素和与经验（例如压力）的相互作用特别敏感。行为灵活性是这些功能的核心属性。这篇评论面向读者的当前景观的文学在啮齿动物实验室实验中的行为灵活性的额叶皮质的基础。研究分为三大类：逆转学习，抑制学习和定势转移。在更广泛的范围内的行为灵活性的功能分离进行审查，然后通过讨论额叶皮层的特定组成部分和相关的行为过程的特定方面之间的关联。最后，作者确定了需要解决的开放性问题，以更好地建立行为灵活性背后的额叶皮层成分。
Research examining the contribution of genetics to behavior is increasingly focused on higher order behavioral and cognitive processes including the ability to modify behaviors when environmental demands change. The frontal cortices of mammals, including rodents, subserve a diverse set of behavioral and cognitive functions including motor planning, social behavior, evaluation of expected outcomes, and working memory which may be particular sensitive to genetic factors and interactions with experience (e.g. stress). Behavioral flexibility is a core attribute of these functions. This review orients readers to the current landscape of the literature on the frontocortical bases of behavioral flexibility in rodent laboratory experiments. Studies are divided into three broad categories: reversal learning, inhibitory learning, and set-shifting. Functional dissociations within the broader scope of behavioral flexibility are reviewed, followed by discussion of the associations between specific components of frontal cortex and specific aspects of relevant behavioral processes. Finally, the authors identify open questions that need to be addressed to better establish the constituents of frontal cortex underlying behavioral flexibility.
登录
查看更多内容
影响因子：
1.7
作者：
Baxter, Mark G.;Gaffan, David
通讯作者：
Gaffan, David
影响因子：
64.8
作者：
Burke, Kathryn A.;Franz, Theresa M.;Schoenbaum, Geoffrey
通讯作者：
Schoenbaum, Geoffrey
DOI：
10.1523/jneurosci.2820-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bissonette GB;Martins GJ;Franz TM;Harper ES;Schoenbaum G;Powell EM
通讯作者：
Powell EM
影响因子：
3
作者：
Bissonette GB;Gentry RN;Padmala S;Pessoa L;Roesch MR
通讯作者：
Roesch MR
影响因子：
1.9
作者：
Bussey, TJ;Everitt, BJ;Robbins, TW
通讯作者：
Robbins, TW