Immunity to Avian Leukosis Virus: Where Are We Now and What Should We Do?

Immunity to Avian Leukosis Virus: Where Are We Now and What Should We Do?
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对禽白血病病毒的免疫力:我们现在在哪里,我们应该做什么?

DOI:
10.3389/fimmu.2016.00624
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发表时间:
2016
影响因子:
7.3
通讯作者:
Zhang X
Zhang X
中科院分区:
医学2区
文献类型:
--
作者:
Feng M;Zhang X

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禽白血病病毒(Avian leukosis virus,ALV)是一种致瘤逆转录病毒,给世界养禽业造成巨大的经济损失。尽管ALV相关研究已经持续了一个多世纪,但目前还没有疫苗来保护鸡免受ALV感染。鸡和ALV之间的相互作用仍然没有完全了解,特别是在宿主免疫方面。目前的审查提供了我们目前的知识ALV感染诱导的先天性和适应性免疫的概述。更重要的是,我们指出了ALV相关研究的未知领域,值得我们在未来认真探索。
Avian leukosis virus (ALV) is an avian oncogenic retrovirus causing enormous economic losses in the global poultry industry. Although ALV-related research has lasted for more than a century, there are no vaccines to protect chickens from ALV infection. The interaction between chickens and ALV remains not fully understood especially with regard to the host immunity. The current review provides an overview of our current knowledge of innate and adaptive immunity induced by ALV infection. More importantly, we have pointed out the unknown area involved in ALV-related studies, which is worthy of our serious exploring in future.
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