Association of maternal and intrauterine characteristics with age at menarche in a multiethnic population in Hawaii.
Association of maternal and intrauterine characteristics with age at menarche in a multiethnic population in Hawaii.
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DOI：
10.1007/s10552-009-9457-1
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Le Marchand L
中科院分区：
文献类型：
--
作者：
Epplein M;Novotny R;Daida Y;Vijayadeva V;Onaka AT;Le Marchand L
本研究旨在进一步阐明母亲和女儿的激素关系，并通过与初潮年龄早的关联，其对女儿的乳腺癌风险的影响。从位于夏威夷奥廷加的HMO招募了438名健康女孩，年龄为9-18岁，白色、亚洲和/或波利尼西亚人种/种族。在门诊访视时进行人体测量，并完成家庭背景调查问卷。考克斯比例风险回归用于检验母体和宫内节育器相关暴露与初潮年龄的关系。出生时的体重和胎龄以及母亲妊娠引起的恶心与初潮年龄无关。母亲初潮年龄每大一岁，女儿初潮年龄提前的风险降低21%（95%CI：0.73-0.86）。对于亚裔、白色和混血、亚裔/白色种族/民族的女孩，母亲和女儿的初潮年龄之间的这种关联具有统计学显著性，但对于混血、部分波利尼西亚种族/民族的女孩则无统计学显著性（pinteraction = 0.01）。有证据表明，母亲乳腺癌史与初潮时过早的风险增加有关（HR = 2.18，95%CI：0.95-4.98）;与二级家族史无关。这些发现支持了这一假设，即母体和宫内节育器相关的暴露与初潮年龄有关。
This study seeks to further elucidate the mother–daughter hormonal relationship and its effects on daughter’s breast cancer risk through the association with early age at menarche. Four hundred and thirty-eight healthy girls, age 9–18 and of White, Asian, and/or Polynesian race/ethnicity, were recruited from an HMO on Oahu, Hawaii. Anthropometric measures were taken at a clinic visit, and family background questionnaires were completed. Cox proportional hazards regression was used to test the association of maternal and intrauterine hormone-related exposures with age at menarche. Weight and gestational age at birth and maternal pregnancy-induced nausea were not associated with age at menarche. Each year older of the mother’s age at menarche was associated with a 21% reduced risk of an early age at menarche for the daughter (95% CI: 0.73–0.86). This association between mother’s and daughter’s menarcheal age was statistically significant for girls of Asian, White, and Mixed, Asian/White race/ethnicity, but not for girls of Mixed, part-Polynesian race/ethnicity (pinteraction = 0.01). There was a suggestion that maternal history of breast cancer was associated with an increased risk of early age at menarche (HR = 2.18, 95% CI: 0.95–4.98); there was no association with second-degree family history. These findings support the hypothesis that maternal and intrauterine hormone-related exposures are associated with age at menarche.
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影响因子：
3.8
作者：
Chavez-MacGregor, Mariana;van Gils, Carla H.;Peeters, Petra H. M.
通讯作者：
Peeters, Petra H. M.
影响因子：
3.5
作者：
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通讯作者：
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影响因子：
5
作者：
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通讯作者：
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影响因子：
2.3
作者：
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通讯作者：
Clavel-Chapelon, F
影响因子：
8
作者：
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通讯作者：
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