Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis.
Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis.
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DOI：
10.3390/ijerph17249160
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发表时间：
2020-12-08
影响因子：
--
通讯作者：
Trimarchi M
中科院分区：
文献类型：
--
作者：
Abati S;Bramati C;Bondi S;Lissoni A;Trimarchi M
口腔癌（oral cancer，OC）是西方国家少见的恶性肿瘤，是世界上一些高危地区最常见的癌症之一。这是一种在很大程度上可以预防的癌症，因为大多数不同的风险因素，如吸烟，饮酒和咀嚼槟榔，都是增加疾病可能性的行为。鉴于其高死亡率，早期诊断至关重要。预防和预测诊断开始与口腔粘膜的潜在恶性病变的识别和促进慢性炎症的局部条件。因此，每一个病变都必须及时识别和适当治疗。口腔粘膜病变的临床识别和评估可以检测高达99%的口腔癌/癌前病变。正如世界卫生组织所指出的，任何可疑的病变，如果在发现和消除局部刺激原因后两周内没有消退，必须进行活检。手术活检仍然是诊断口腔癌的金标准。辅助工具已经开发和研究，以帮助临床医生在诊断途径，如甲苯胺蓝活体染色和自体荧光成像。在不久的将来，其他方法，即，确定唾液中的进展标志物可能有助于降低口腔癌的死亡率。
Oral cancer (OC) is an uncommon malignancy in Western countries, being one of the most common cancers in some high-risk areas of the world. It is a largely preventable cancer, since most of the different risk factors identified, such as tobacco use, alcohol consumption, and betel nut chewing, are behaviors that increase the likelihood of the disease. Given its high mortality, early diagnosis is of utmost importance. Prevention and the anticipation of diagnosis begin with identification of potentially malignant lesions of the oral mucosa and with local conditions promoting chronic inflammation. Therefore, every lesion must be recognized promptly and treated adequately. The clinical recognition and evaluation of oral mucosal lesions can detect up to 99% of oral cancers/premalignancies. As stated by the World Health Organization, any suspicious lesion that does not subside within two weeks from detection and removal of local causes of irritation must be biopsied. Surgical biopsy remains the gold standard for diagnosis of oral cancer. Adjunctive tools have been developed and studied to help clinicians in the diagnostic pathway, such as toluidine blue vital staining and autofluorescence imaging. In the near future other methods, i.e., identification of salivary markers of progression may help in reducing mortality due to oral cancer.
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影响因子：
2.4
作者：
de Veld, DCG;Skurichina, M;Roodenburg, JLN
通讯作者：
Roodenburg, JLN
影响因子：
5.1
作者：
Franzmann, Elizabeth J.;Donovan, Michael J.
通讯作者：
Donovan, Michael J.
影响因子：
2.2
作者：
Cerero-Lapiedra, Rocio;Balade-Martinez, David;Bagan, Jose V.
通讯作者：
Bagan, Jose V.
影响因子：
4.8
作者：
Groome, Patti A.;Rohland, Susan L.;O'Sullivan, Brian
通讯作者：
O'Sullivan, Brian
DOI：
10.4317/medoral.21999
发表时间：
2018-01-01
期刊：
Medicina oral, patologia oral y cirugia bucal
影响因子：
--
作者：
Dhanuthai K;Rojanawatsirivej S;Thosaporn W;Kintarak S;Subarnbhesaj A;Darling M;Kryshtalskyj E;Chiang CP;Shin HI;Choi SY;Lee SS;Aminishakib P
通讯作者：
Aminishakib P