Specific resistance prevents the evolution of general resistance and facilitates disease emergence.
Specific resistance prevents the evolution of general resistance and facilitates disease emergence.
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DOI：
10.1111/jeb.14170
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发表时间：
2023-05
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
--
作者：
宿主转移，即病原体从祖先宿主跳到新宿主，可以通过抗病性的持续变化来促进或阻碍，但只有当抗性提供针对多种病原体物种的广谱一般抗性时。宿主抗性有多种形式，包括一般抗性和特异性抗性，特异性抗性可能仅对单一病原体物种或甚至基因型有效。然而，大多数进化模型只考虑其中一种形式的抵抗，我们对这两种形式的抵抗如何协同进化的了解较少。在这里，我们开发了一个模型，允许特定的和一般的电阻的联合进化，并询问特定电阻的进化是否会导致一般电阻的进化减少。我们还探讨了这些进化结果如何影响外来病原体入侵和持久性的风险。我们表明，在一个单一的地方病病原体的存在下，这两种形式的阻力是强烈的排他性。重要的是，我们发现特异性耐药多态性可以阻止一般耐药的演变，促进外来病原体的入侵。我们还表明，特定的耐药多态性是成功建立外来病原体入侵后的必要条件，因为它们可以防止外来病原体被更具传播性的地方病病原体排除。我们的结果表明，在评估人群对外来病原体的易感性时，考虑多种形式抗性的联合进化非常重要。
Host-shifts, where pathogens jump from an ancestral host to a novel host, can be facilitated or impeded by standing variation in disease resistance, but only if resistance provides broad-spectrum general resistance against multiple pathogen species. Host resistance comes in many forms and includes both general resistance, as well as specific resistance, which may only be effective against a single pathogen species or even genotype. However, most evolutionary models consider only one of these forms of resistance, and we have less understanding of how these two forms of resistance evolve in tandem. Here, we develop a model that allows for the joint evolution of specific and general resistance and asks if the evolution of specific resistance drives a decrease in the evolution of general resistance. We also explore how these evolutionary outcomes affect the risk of foreign pathogen invasion and persistence. We show that in the presence of a single endemic pathogen, the two forms of resistance are strongly exclusionary. Critically, we find that specific resistance polymorphisms can prevent the evolution of general resistance, facilitating the invasion of foreign pathogens. We also show that specific resistance polymorphisms are a necessary condition for the successful establishment of foreign pathogens following invasion, as they prevent the exclusion of the foreign pathogen by the more transmissible endemic pathogen. Our results demonstrate the importance of considering the joint evolution of multiple forms of resistance when evaluating a population's susceptibility to foreign pathogens.
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影响因子：
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DOI：
10.1111/evo.13623
发表时间：
2018-12
期刊：
Evolution; international journal of organic evolution
影响因子：
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作者：
Bartlett LJ;Wilfert L;Boots M
通讯作者：
Boots M
DOI：
10.1111/evo.13216
发表时间：
2017-05
期刊：
Evolution; international journal of organic evolution
影响因子：
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作者：
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Godfray HCJ
DOI：
10.1086/715013
发表时间：
2021-08
期刊：
The American naturalist
影响因子：
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作者：
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通讯作者：
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