Anopheles mosquitoes may drive invasion and transmission of Mayaro virus across geographically diverse regions.
Anopheles mosquitoes may drive invasion and transmission of Mayaro virus across geographically diverse regions.
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DOI：
10.1371/journal.pntd.0006895
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发表时间：
2018-11
影响因子：
3.8
通讯作者：
Rasgon JL
中科院分区：
文献类型：
--
作者：
Brustolin M;Pujhari S;Henderson CA;Rasgon JL
披膜病毒（甲病毒）马亚罗病毒（MAYV）最初于1954年在马亚罗县（特立尼达）被描述，并在南美洲和加勒比地区爆发。输入性MAYV病例正在上升，导致类似于基孔肯雅病毒和寨卡病毒的入侵担忧。对作为MAYV有效载体的蚊子种类的范围知之甚少。我们在六种蚊子的实验室品系中检测了2种MAYV基因型的载体能力（埃及伊蚊、自由按蚊、按蚊、埃及伊蚊、gambiae、冈比亚角隐翅虫An. quadramaculatus，四斑隐翅虫An. stephensi、致倦库蚊Culex quinquefasciatus）。AE.埃及和Cx.致倦犬是较差的MAYV载体，并且在测试的病毒攻击滴度下具有较差或零感染和传播率。与此相反，所有的按蚊种都能够传播MAYV，和4种传播两种基因型的3。测试的按蚊种是不同的，原产于广泛分离的地理区域（非洲，亚洲，北美），这表明按蚊可能是重要的MAYV在世界不同地区的入侵和传播。马亚罗病毒（MAYV）是一种蚊子传播的甲病毒，在南美洲和加勒比地区爆发。在这项研究中，我们用MAYV感染不同种类的蚊子（属于伊蚊属、按蚊属和库蚊属），并测试它们在不同时间点传播病毒的能力。结果表明，按蚊是2种基因型MAYV的适传媒介，而伊蚊和库蚊是弱传媒介。按蚊传播MAYV的能力突出了它们作为被忽视的虫媒病毒载体的重要性。这些数据表明，按蚊有可能在包括美国在内的未感染地区维持被忽视病原体的传播周期。
The Togavirus (Alphavirus) Mayaro virus (MAYV) was initially described in 1954 from Mayaro County (Trinidad) and has been responsible for outbreaks in South America and the Caribbean. Imported MAYV cases are on the rise, leading to invasion concerns similar to Chikungunya and Zika viruses. Little is known about the range of mosquito species that are competent MAYV vectors. We tested vector competence of 2 MAYV genotypes in laboratory strains of six mosquito species (Aedes aegypti, Anopheles freeborni, An. gambiae, An. quadrimaculatus, An. stephensi, Culex quinquefasciatus). Ae. aegypti and Cx. quinquefasciatus were poor MAYV vectors, and had either poor or null infection and transmission rates at the tested viral challenge titers. In contrast, all Anopheles species were able to transmit MAYV, and 3 of the 4 species transmitted both genotypes. The Anopheles species tested are divergent and native to widely separated geographic regions (Africa, Asia, North America), suggesting that Anopheles may be important in the invasion and spread of MAYV across diverse regions of the world. Mayaro virus (MAYV) is a mosquito-borne Alphavirus responsible for outbreaks in South America and the Caribbean. In this study we infected different species of mosquito (belonging to the genera Aedes, Anopheles and Culex) with MAYV and tested their capacity to transmit the virus at different time points. Results show that Anopheles mosquitoes were competent vectors for 2 genotypes of MAYV, while Aedes and Culex were poor vectors. The capacity of Anopheles mosquitoes to transmit MAYV highlights their importance as neglected vectors of arboviruses. These data suggest that Anopheles mosquitoes have the potential to sustain transmission cycles of neglected pathogens in naïve regions, including the United States.
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影响因子：
11.8
作者：
Lednicky J;De Rochars VM;Elbadry M;Loeb J;Telisma T;Chavannes S;Anilis G;Cella E;Ciccozzi M;Okech B;Salemi M;Morris JG Jr
通讯作者：
Morris JG Jr
影响因子：
1.9
作者：
Wiggins, K.;Eastmond, B.;Alto, B. W.
通讯作者：
Alto, B. W.
DOI：
10.4269/ajtmh.1967.16.525
发表时间：
1967-01-01
影响因子：
3.3
作者：
GALINDO, P;SRIHONGSE, S
通讯作者：
SRIHONGSE, S
影响因子：
2.7
作者：
Dodson BL;Rasgon JL
通讯作者：
Rasgon JL
影响因子：
3.4
作者：
Alves Esposito, Danillo Lucas;Lopes da Fonseca, Benedito Antonio
通讯作者：
Lopes da Fonseca, Benedito Antonio