Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4⁺ memory T Cells.
Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4⁺ memory T Cells.
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DOI：
10.1038/ncomms6407
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发表时间：
2014-11-10
影响因子：
16.6
通讯作者：
Taoufik, Y.
中科院分区：
文献类型：
--
作者：
Jaafoura, S.;de Herve, M. G. de Goer;Hernandez-Vargas, E. A.;Hendel-Chavez, H.;Abdoh, M.;Mateo, M. C.;Krzysiek, R.;Merad, M.;Seng, R.;Tardieu, M.;Delfraissy, J. F.;Goujard, C.;Taoufik, Y.
在接受长期抗逆转录病毒治疗(ART)的患者中，艾滋病毒可以持续存在于感染了整合潜伏病毒的长期静止记忆CD4+T细胞的小池中。这种潜在的储藏库涉及不同的记忆子集。在这里，我们提供的结果表明，围绕着分化较少的记忆亚群(中央记忆和干细胞样记忆(TSCM)CD4+T细胞)核心的血液潜伏库的大小逐渐减小。这一过程似乎是由潜伏感染的记忆子集之间的初始大小和衰减率的差异推动的。我们的结果还表明，TSCM亚库具有极高的稳定性，其大小与ART发病前累积的血浆病毒暴露直接相关，强调了及早启动有效ART的重要性。潜伏库中这些内在动力的存在可能会对设计最佳的HIV治疗性清除策略产生影响。HIV可以在接受长期抗逆转录病毒治疗的患者的CD4+T细胞中持续存在。在这里，作者展示了内在动力的存在，它逐渐收缩了围绕着分化较少的CD4T细胞记忆亚集的核心的潜伏的艾滋病毒储存库。
In patients who are receiving prolonged antiretroviral treatment (ART), HIV can persist within a small pool of long-lived resting memory CD4+ T cells infected with integrated latent virus. This latent reservoir involves distinct memory subsets. Here we provide results that suggest a progressive reduction of the size of the blood latent reservoir around a core of less-differentiated memory subsets (central memory and stem cell-like memory (TSCM) CD4+ T cells). This process appears to be driven by the differences in initial sizes and decay rates between latently infected memory subsets. Our results also suggest an extreme stability of the TSCM sub-reservoir, the size of which is directly related to cumulative plasma virus exposure before the onset of ART, stressing the importance of early initiation of effective ART. The presence of these intrinsic dynamics within the latent reservoir may have implications for the design of optimal HIV therapeutic purging strategies. HIV can persist in CD4+ T cells of patients receiving long-term antiretroviral therapy. Here the authors show the presence of intrinsic dynamics that progressively contract the latent HIV reservoir around a core of less-differentiated CD4 T-cell memory subsets.
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影响因子：
82.9
作者：
Gattinoni L;Lugli E;Ji Y;Pos Z;Paulos CM;Quigley MF;Almeida JR;Gostick E;Yu Z;Carpenito C;Wang E;Douek DC;Price DA;June CH;Marincola FM;Roederer M;Restifo NP
通讯作者：
Restifo NP
影响因子：
5.4
作者：
Hernandez-Vargas, Esteban A.;Wilk, Esther;Meyer-Hermann, Michael
通讯作者：
Meyer-Hermann, Michael
DOI：
10.1073/pnas.94.24.13193
发表时间：
1997-11-25
影响因子：
11.1
作者：
Chun, TW;Stuyver, L;Fauci, AS
通讯作者：
Fauci, AS
影响因子：
3.8
作者：
Sauce, Delphine;Almeida, Jorge R.;Appay, Victor
通讯作者：
Appay, Victor
影响因子：
5
作者：
Cole, Stephen R.;Napravnik, Sonia;Saag, Michael S.
通讯作者：
Saag, Michael S.