A Chlorfenapyr Mixture Net Interceptor® G2 Shows High Efficacy and Wash Durability against Resistant Mosquitoes in West Africa.
A Chlorfenapyr Mixture Net Interceptor® G2 Shows High Efficacy and Wash Durability against Resistant Mosquitoes in West Africa.
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DOI：
10.1371/journal.pone.0165925
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Rowland M
中科院分区：
文献类型：
--
作者：
N'Guessan R;Odjo A;Ngufor C;Malone D;Rowland M
通过使用长效杀虫蚊帐（LN）控制疟疾受到对拟除虫菊酯杀虫剂具有强抗药性的按蚊选择的威胁。为了维持未来的有效性，有必要识别和评估适合蚊帐的新型杀虫剂。具有对比作用方式的两种杀虫剂的混合物有可能杀死抗药性媒介并恢复传播控制，前提是该制剂能够在蚊帐的使用寿命内承受定期清洗。新型混合物 LN Interceptor® G2 结合了吡咯虫螨腈和拟除虫菊酯 α-氯氰菊酯，其功效在受控的家庭条件下（实验小屋试验）和针对拟除虫菊酯抗性 An 的实验室生物测定进行了评估。贝宁的冈比亚标准化清洗前后。比较组包括标准甲型氯氰菊酯液氮、仅用氯芬吡手工处理过的蚊帐和未经处理的蚊帐。与标准甲型氯氰菊酯液剂相比，氟虫腈-甲型氯氰菊酯液剂对拟除虫菊酯耐药的蚊子表现出更好的功效和耐洗性（耐药比为 207）。在实验小屋试验中，α-氯氰菊酯液氮仅杀死了 20%（95% CI 15-26%）的寻求寄主的按蚊。冈比亚，而混合物 LN 杀死了 71% (95% CI 65–77%)。混合物液氮清洗 20 次可杀死 65%（95% CI 58–71%），因此强化清洗仅使功效降低 6%（95% CI 1.3–11%）。虫螨吡净杀死了 76%（95% CI 70-81%）。混合物和拟除虫菊酯液氮之间的个人防护和血液喂养抑制没有差异；然而，混合物 LN 的保护作用比未经处理的网高 2.5 倍（95% CI：2.1-3.1）。白天进行的标准世界卫生组织锥体生物测定未能预测现场功效，但夜间隧道试验成功预测了现场试验中 LN 和虫螨腈混合物的净功效。 Interceptor® G2 LN 展示了在长效蚊帐的正常使用寿命内控制传播和提供社区保护的潜力，而标准拟除虫菊酯 LN 由于耐药性而出现失效迹象。
Malaria control through use of long-lasting insecticidal nets (LN) is threatened by the selection of anopheline mosquitoes strongly resistant to pyrethroid insecticides. To sustain future effectiveness it is essential to identify and evaluate novel insecticides suitable for nets. Mixtures of two insecticides with contrasting mode of action have the potential to kill resistant vectors and restore transmission control provided the formulation can withstand regular washing over the net’s life span. The efficacy of a novel mixture LN, Interceptor® G2, that combines the pyrrole chlorfenapyr and pyrethroid alpha-cypermethrin was evaluated under controlled household conditions (experimental hut trial) and by laboratory bioassay against pyrethroid resistant An. gambiae in Benin before and after standardized washing. Comparison arms included standard alpha-cypermethrin LN, nets hand-treated with chlorfenapyr-only and untreated nets. The chlorfenapyr-alphacypermethrin LN demonstrated improved efficacy and wash resistance compared to a standard alpha-cypermethrin LN against pyrethroid resistant mosquitoes (resistance ratio 207). In experimental hut trial alpha-cypermethrin LN killed only 20% (95% CI 15–26%) of host-seeking An. gambiae whilst mixture LN killed 71% (95% CI 65–77%). Mixture LN washed 20 times killed 65% (95% CI 58–71%), and thus intensive washing reduced efficacy by only 6% (95% CI 1.3–11%). The chlorfenapyr net killed 76% (95% CI 70–81%). Personal protection and blood feeding inhibition did not differ between mixture and pyrethroid LN; however, the mixture LN was 2.5 (95% CI: 2.1–3.1) times more protective than untreated nets. Standard WHO cone bioassays conducted during day time hours failed to anticipate field efficacy but overnight tunnel tests successfully predicted mixture LN and chlorfenapyr net efficacy in field trials. Interceptor® G2 LN demonstrates the potential to control transmission and provide community protection over the normal lifespan of long lasting nets where standard pyrethroid LN show signs of failing due to resistance.
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影响因子：
3.2
作者：
Knox TB;Juma EO;Ochomo EO;Pates Jamet H;Ndungo L;Chege P;Bayoh NM;N'Guessan R;Christian RN;Hunt RH;Coetzee M
通讯作者：
Coetzee M
影响因子：
3.2
作者：
Tungu, Patrick;Kirby, Matthew;Rowland, Mark
通讯作者：
Rowland, Mark
影响因子：
11.8
作者：
Asidi A;N'Guessan R;Akogbeto M;Curtis C;Rowland M
通讯作者：
Rowland M
影响因子：
3.2
作者：
Malima, Robert;Tungu, Patrick K.;Rowland, Mark
通讯作者：
Rowland, Mark
影响因子：
3.7
作者：
West PA;Protopopoff N;Wright A;Kivaju Z;Tigererwa R;Mosha FW;Kisinza W;Rowland M;Kleinschmidt I
通讯作者：
Kleinschmidt I