An online tool for mapping insecticide resistance in major Anopheles vectors of human malaria parasites and review of resistance status for the Afrotropical region.
An online tool for mapping insecticide resistance in major Anopheles vectors of human malaria parasites and review of resistance status for the Afrotropical region.
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DOI：
10.1186/1756-3305-7-76
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发表时间：
2014-02-21
影响因子：
3.2
通讯作者：
Coetzee M
中科院分区：
文献类型：
--
作者：
Knox TB;Juma EO;Ochomo EO;Pates Jamet H;Ndungo L;Chege P;Bayoh NM;N'Guessan R;Christian RN;Hunt RH;Coetzee M
非洲及其他地区的疟疾防治方案正面临着主要按蚊病媒对杀虫剂的抗药性日益增加的问题。为了保持或延长主要疟疾病媒干预措施的有效性，最新和容易获得的、可在业务相关规模上解释的杀虫剂抗药性数据至关重要。在这里，我们介绍和演示的在线映射工具，IR映射器的实用性。对已发表的同行评议文献进行了系统检索，提取了按蚊杀虫剂敏感性和抗性机制数据，并在两级验证过程后将其添加到数据库中。IR Mapper（http://www.irmapper.com）是使用ArcGIS for JavaScript应用程序编程接口和ArcGIS Online平台开发的，用于探索和投影这些数据。文献检索共获得1，505个按蚊种群的4，084个易感性数据点，以及1，000个按蚊种群的2，097个耐药机制数据点。在1954年至2012年期间，通过世卫组织推荐的54个国家的方法进行了测试。在非洲热带地区，数据最丰富的人口的安。与氨基甲酸酯和有机磷酸酯相比，拟除虫菊酯和滴滴涕更常用于敏感性测定（分别占所有报告的51.1%和26.8%）。2001年至2012年，确认的耐药性的流行率和分布明显增加。冈比亚有限公司在整个非洲热带地区，对拟除虫菊酯（占所测试蚊子种群的41%至87%）和滴滴涕（占64%至91%）的敏感性增加。在西非和东非人群中检测到代谢抗性机制，并且两种kdr突变（L1014 S和L1014 F）广泛存在。为了安。funestus s.l.，虽然在2010-2012年期间，10个受试种群中有50%报告出现抗药性，但受试种群相对较少。提供的地图说明了IR Mapper的使用情况和非洲疟疾病媒对杀虫剂的抗药性分布情况。非洲热带地区按蚊对拟除虫菊酯和滴滴涕的抗药性日益增加，令人震惊。应立即注意对An进行测试。尤其是代谢抗性机制。IR Mapper是调查按蚊抗药性时空趋势的有用工具，可支持杀虫剂干预措施的实际应用。
Malaria control programmes across Africa and beyond are facing increasing insecticide resistance in the major anopheline vectors. In order to preserve or prolong the effectiveness of the main malaria vector interventions, up-to-date and easily accessible insecticide resistance data that are interpretable at operationally-relevant scales are critical. Herein we introduce and demonstrate the usefulness of an online mapping tool, IR Mapper. A systematic search of published, peer-reviewed literature was performed and Anopheles insecticide susceptibility and resistance mechanisms data were extracted and added to a database after a two-level verification process. IR Mapper ( http://www.irmapper.com) was developed using the ArcGIS for JavaScript Application Programming Interface and ArcGIS Online platform for exploration and projection of these data. Literature searches yielded a total of 4,084 susceptibility data points for 1,505 populations, and 2,097 resistance mechanisms data points for 1,000 populations of Anopheles spp. tested via recommended WHO methods from 54 countries between 1954 and 2012. For the Afrotropical region, data were most abundant for populations of An. gambiae, and pyrethroids and DDT were more often used in susceptibility assays (51.1 and 26.8% of all reports, respectively) than carbamates and organophosphates. Between 2001 and 2012, there was a clear increase in prevalence and distribution of confirmed resistance of An. gambiae s.l. to pyrethroids (from 41 to 87% of the mosquito populations tested) and DDT (from 64 to 91%) throughout the Afrotropical region. Metabolic resistance mechanisms were detected in western and eastern African populations and the two kdr mutations (L1014S and L1014F) were widespread. For An. funestus s.l., relatively few populations were tested, although in 2010–2012 resistance was reported in 50% of 10 populations tested. Maps are provided to illustrate the use of IR Mapper and the distribution of insecticide resistance in malaria vectors in Africa. The increasing pyrethroid and DDT resistance in Anopheles in the Afrotropical region is alarming. Urgent attention should be afforded to testing An. funestus populations especially for metabolic resistance mechanisms. IR Mapper is a useful tool for investigating temporal and spatial trends in Anopheles resistance to support the pragmatic use of insecticidal interventions.
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DOI：
10.4269/ajtmh.2003.69.200
发表时间：
2003-08-01
影响因子：
3.3
作者：
Cohuet, A;Simard, F;Fontenille, D
通讯作者：
Fontenille, D
影响因子：
3.8
作者：
della Torre, A;Tu, ZJ;Petrarca, V
通讯作者：
Petrarca, V
影响因子：
3
作者：
Gething PW;Patil AP;Smith DL;Guerra CA;Elyazar IR;Johnston GL;Tatem AJ;Hay SI
通讯作者：
Hay SI
影响因子：
3.7
作者：
Kulkarni, Manisha A.;Desrochers, Rachelle E.;Kerr, Jeremy T.
通讯作者：
Kerr, Jeremy T.
DOI：
10.1098/rspb.1998.0369
发表时间：
1998-05-22
影响因子：
4.7
作者：
Lindsay, SW;Parson, L;Thomas, CJ
通讯作者：
Thomas, CJ