Serum uric acid and 1-h postload glucose in essential hypertension.
Serum uric acid and 1-h postload glucose in essential hypertension.
复制标题
DOI：
10.2337/dc11-1727
复制
发表时间：
2012-01
期刊：
影响因子：
16.2
通讯作者：
Sesti G
中科院分区：
文献类型：
--
作者：
Perticone F;Sciacqua A;Perticone M;Arturi F;Scarpino PE;Quero M;Sesti G
正常糖耐量 (NGT) 的受试者被认为处于低风险，即使口服葡萄糖耐量试验 (OGTT) 期间 1 小时负荷后血糖的血浆葡萄糖值≥155 mg/dL 也能够识别处于 2 型糖尿病和亚临床器官损伤高风险的 NGT 受试者。高尿酸血症与高血压、胰岛素抵抗和糖尿病等心血管疾病的多种危险因素有关。然而，尚不清楚尿酸 (UA) 是否能够影响高血压 NGT 受试者的 1 小时负荷后血糖。从约 1,200 名接受 OGTT 的无并发症高血压门诊患者队列中，我们选择了 955 名受试者（548 名男性和 407 名女性），年龄为 45.6 ± 10.1 岁。进行了实验室评估，并使用慢性肾脏病流行病学合作组织研究人员提出的新方程评估了估计的肾小球滤过率。考虑到不同的逐步多元线性回归模型，UA是整个人群1小时负荷后血糖的主要预测因子，NGT≥155受试者、糖耐量受损和2型糖尿病患者分别占26.0%（P < 0.0001）、25.3%（P < 0.0001）、13.5%（P < 0.0001）和13.5% (P = 0.003) 其在各个模型中的变化。我们记录到，在高血压 NGT ≥155 受试者中，UA 与负荷后 1 小时血糖密切相关，类似于在糖耐量受损和糖尿病患者中观察到的情况。
Subjects who are normal glucose tolerant (NGT) are considered at low risk, even if a plasma glucose value ≥155 mg/dL for the 1-h postload plasma glucose during an oral glucose tolerance test (OGTT) is able to identify NGT subjects at high risk for type 2 diabetes and subclinical organ damage. Hyperuricemia is associated with several risk factors for cardiovascular diseases such as hypertension, insulin resistance, and diabetes. However, it is unknown whether uric acid (UA) is able to affect 1-h postload plasma glucose in hypertensive NGT subjects. From a cohort of ∼1,200 uncomplicated hypertensive outpatients who underwent OGTT, we selected 955 subjects (548 men and 407 women) aged 45.6 ± 10.1 years. Laboratory evaluations were performed, and estimated glomerular filtration rate was assessed by using the new equation proposed by investigators in the Chronic Kidney Disease Epidemiology Collaboration. Considering different stepwise multivariate linear regression models, UA was the major predictor of 1-h postload glucose in the entire population, with NGT ≥155 subjects, impaired glucose tolerant, and type 2 diabetic patients accounting for 26.0% (P < 0.0001), 25.3% (P < 0.0001), 13.5% (P < 0.0001), and 13.5% (P = 0.003) of its variation in the respective models. We documented that in hypertensive NGT ≥155 subjects, UA is strongly associated with 1-h postload glucose, similarly to what is observed in impaired glucose tolerant and diabetic patients.
登录
查看更多内容
影响因子：
19.6
作者：
Khosla, UM;Zharikov, S;Johnson, RJ
通讯作者：
Johnson, RJ
影响因子：
15.9
作者：
So, Alexander;Thorens, Bernard
通讯作者：
Thorens, Bernard
影响因子：
105.7
作者：
Huxley, R;Barzi, F;Woodward, M
通讯作者：
Woodward, M
影响因子：
8.3
作者：
Bos, Michiel J.;Koudstaal, Peter J.;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
DOI：
10.2215/cjn.03240410
发表时间：
2010-11-01
影响因子：
9.8
作者：
Succurro, Elena;Arturi, Franco;Sesti, Giorgio
通讯作者：
Sesti, Giorgio