Inhalation toxicity of humidifier disinfectants as a risk factor of children's interstitial lung disease in Korea: a case-control study.
Inhalation toxicity of humidifier disinfectants as a risk factor of children's interstitial lung disease in Korea: a case-control study.
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DOI：
10.1371/journal.pone.0064430
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hong SJ
中科院分区：
文献类型：
--
作者：
Yang HJ;Kim HJ;Yu J;Lee E;Jung YH;Kim HY;Seo JH;Kwon GY;Park JH;Gwack J;Youn SK;Kwon JW;Jun BY;Kim KW;Ahn K;Lee SY;Park JD;Kwon JW;Kim BJ;Lee MS;Do KH;Jang SJ;Pyun BY;Hong SJ
从2006年开始，韩国每年春季都会发生大量儿童间质性肺病病例，这引起了人们对使用湿化器消毒剂（HD）的因果关系的怀疑。本研究的目的是评价HD使用与儿童ILD风险之间的相关性。这项回顾性、1∶3匹配的病例对照研究包括2010年至2011年间发生的16例儿童ILD病例。三组平行对照组（急性大叶性肺炎患者、哮喘患者和健康儿童）在年龄、性别和索引日期上匹配。通过要求监护人填写问卷调查了室内/室外环境风险因素，包括HD使用。受影响儿童的中位年龄（43.8%为男性）为26个月（18.25-36.25）。儿童组在社会人口统计学和临床变量方面与对照组无显著差异。室内和室外环境因素与儿童ILD的风险无关。然而，以前使用过HD（OR; 2.73。95%CI; 1.41-5.90，P = 0.00）与风险增加独立相关。 这项研究表明，在韩国冬季广泛使用的HDs独立增加了春季儿童的风险。因此，持续监测和必要时改变政策对于预防和控制有毒化学品引起的儿科疾病至关重要。
The occurrence of numerous cases of interstitial lung disease in children (chILD) every spring in Korea starting in 2006 raised suspicion about a causal relationship with the use of humidifier disinfectants (HDs). The aim of this study was to evaluate the association between HD use and the risk of chILD. This retrospective, 1∶3 matched case-control study consisted of 16 cases of chILD that had developed between 2010 and 2011. The three groups of parallel controls (patients with acute lobar pneumonia, asthma, and healthy children) were matched by age, gender, and index date. Indoor/outdoor environmental risk factors, including HD use, were investigated by asking the guardians to complete a questionnaire. The median age of the affected children (43.8% male) was 26 months (18.25–36.25). The chILD group did not differ significantly from the control groups with respect to socio-demographic and clinical variables. Indoor and outdoor environmental factors were not associated with a risk of chILD. However, the previous use of HDs (OR; 2.73. 95% CI; 1.41–5.90, P = 0.00) were independently associated with an increased risk. This study showed that HDs, which are widely used in South Korea in the winter season, independently increased the risk of chILD in spring. Therefore, continuous monitoring and, if needed, changes in policy are essential to prevent and control pediatric diseases caused by toxic chemicals.
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DOI：
10.4168/aair.2012.4.4.240
发表时间：
2012-07
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Lee E;Seo JH;Kim HY;Yu J;Song JW;Park YS;Jang SJ;Do KH;Kwon J;Park SW;Park JH;Hong SJ
通讯作者：
Hong SJ
影响因子：
2.1
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通讯作者：
Spielmann, Horst
影响因子：
0.6
作者：
Müller-Wening, D;Koschel, D;Sennekamp, HJ
通讯作者：
Sennekamp, HJ
DOI：
10.1007/s00128-011-0436-3
发表时间：
2012-03-01
影响因子：
2.7
作者：
Lucas, Anne D.
通讯作者：
Lucas, Anne D.
DOI：
10.1016/j.nano.2009.04.006
发表时间：
2010-02-01
影响因子：
5.4
作者：
Fayaz, Amanulla Mohammed;Balaji, Kulandaivelu;Venketesan, Ramasamy
通讯作者：
Venketesan, Ramasamy