Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans.
Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans.
复制标题
DOI：
10.1186/1743-7075-7-18
复制
发表时间：
2010-03-05
影响因子：
4.5
通讯作者：
Chew BP
中科院分区：
文献类型：
--
作者：
Park JS;Chyun JH;Kim YK;Line LL;Chew BP
在体外和啮齿动物模型中，虾青素调节免疫反应，抑制癌细胞生长，减少细菌负荷和胃炎症，并保护免受UVA诱导的氧化应激。目前还没有类似的人体临床研究。我们的目标是研究膳食虾青素在调节年轻健康成年女性受试者的免疫应答、氧化状态和炎症中的作用。参与者（平均21.5岁）在一项随机双盲、安慰剂对照研究中每天接受0、2或8 mg虾青素（n = 14/饮食），持续8周。在第0、4和8周评估免疫应答，并在第8周进行结核菌素试验。血浆虾青素在补充4或8 wk后呈剂量依赖性增加（P < 0.01）。4周后，虾青素降低了DNA损伤生物标志物，但不影响脂质过氧化。在第8周，给予2 mg虾青素的受试者的血浆C反应蛋白浓度较低（P < 0.05）。膳食虾青素刺激有丝分裂原诱导的淋巴细胞增殖，增加自然杀伤细胞的细胞毒活性，并增加总的T和B细胞亚群，但不影响人口的Thelper，T细胞毒性或自然杀伤细胞。在第8周给予2 mg虾青素的受试者中，白细胞表达LFA-1标志物的百分比较高。喂食2毫克虾青素的受试者比未补充的受试者有更高的结核菌素反应。在给予8 mg虾青素的受试者中，TNF和IL-2浓度没有差异，但血浆IFN-γ和IL-6在第8周增加。因此，膳食虾青素降低了DNA损伤生物标志物和急性期蛋白，并增强了年轻健康女性的免疫反应。
Astaxanthin modulates immune response, inhibits cancer cell growth, reduces bacterial load and gastric inflammation, and protects against UVA-induced oxidative stress in in vitro and rodent models. Similar clinical studies in humans are unavailable. Our objective is to study the action of dietary astaxanthin in modulating immune response, oxidative status and inflammation in young healthy adult female human subjects. Participants (averaged 21.5 yr) received 0, 2, or 8 mg astaxanthin (n = 14/diet) daily for 8 wk in a randomized double-blind, placebo-controlled study. Immune response was assessed on wk 0, 4 and 8, and tuberculin test performed on wk 8. Plasma astaxanthin increased (P < 0.01) dose-dependently after 4 or 8 wk of supplementation. Astaxanthin decreased a DNA damage biomarker after 4 wk but did not affect lipid peroxidation. Plasma C-reactive protein concentration was lower (P < 0.05) on wk 8 in subjects given 2 mg astaxanthin. Dietary astaxanthin stimulated mitogen-induced lymphoproliferation, increased natural killer cell cytotoxic activity, and increased total T and B cell subpopulations, but did not influence populations of Thelper, Tcytotoxic or natural killer cells. A higher percentage of leukocytes expressed the LFA-1 marker in subjects given 2 mg astaxanthin on wk 8. Subjects fed 2 mg astaxanthin had a higher tuberculin response than unsupplemented subjects. There was no difference in TNF and IL-2 concentrations, but plasma IFN-γ and IL-6 increased on wk 8 in subjects given 8 mg astaxanthin. Therefore, dietary astaxanthin decreases a DNA damage biomarker and acute phase protein, and enhances immune response in young healthy females.
登录
查看更多内容
影响因子：
3.9
作者：
Gershon, D
通讯作者：
Gershon, D
影响因子：
3.4
作者：
McNulty, Hyesun P.;Byun, Jungsoo;Mason, R. Preston
通讯作者：
Mason, R. Preston
影响因子：
6
作者：
Naito, Y;Uchiyama, K;Yoshikawa, T
通讯作者：
Yoshikawa, T
影响因子：
3.3
作者：
Bejma, J;Ji, LL
通讯作者：
Ji, LL
影响因子：
2.9
作者：
JYONOUCHI, H;ZHANG, L;TOMITA, Y
通讯作者：
TOMITA, Y