An Overview of Potential Natural Photosensitizers in Cancer Photodynamic Therapy.
An Overview of Potential Natural Photosensitizers in Cancer Photodynamic Therapy.
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DOI：
10.3390/biomedicines11010224
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发表时间：
2023-01-16
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
癌症是全球主要的死亡原因之一。迄今为止，有几种不同类型的癌症被认识到，它们可以通过不同的方法治疗，包括手术、放疗、化疗或其组合。然而，这些方法具有某些缺点和限制。光动力疗法（PDT）被认为是一种基于在治疗部位产生有毒氧（称为活性氧（ROS））的癌症治疗的替代非侵入性方法。PDT需要通过光敏剂（PS）在分子氧（单线态氧）附近以特定波长（λ）的光进行光活化。在PS光活化的PDT中采用的细胞死亡机制是坏死、凋亡和免疫系统的刺激。在过去的几十年里，使用天然化合物作为选择性根除肿瘤病变的光敏剂引起了研究人员的注意。许多评论都集中在PS细胞死亡的作用模式和PDT的光纳米医学方法，而有限的注意力已经支付给植物化合物的光活化。光活化在自然界中一直存在，也存在于天然植物化合物中。各种激光装置的可用性可以在发现可用作天然PS的光敏植物化合物方面发挥重要作用。探索植物化合物的光活性特性可以揭示新的天然化合物，可以在未来的药物研究中用作PS。在这篇综述中，我们强调了目前的研究关于几个光敏植物化合物类（呋喃香豆素，生物碱，聚乙炔和噻吩，姜黄素，黄酮类化合物，蒽醌类化合物，和天然提取物）和它们的光敏潜力，鼓励研究人员专注于研究天然药物和它们作为一个强大的PS，以提高PDT的效率。
Cancer is one of the main causes of death worldwide. There are several different types of cancer recognized thus far, which can be treated by different approaches including surgery, radiotherapy, chemotherapy or a combination thereof. However, these approaches have certain drawbacks and limitations. Photodynamic therapy (PDT) is regarded as an alternative noninvasive approach for cancer treatment based on the generation of toxic oxygen (known as reactive oxygen species (ROS)) at the treatment site. PDT requires photoactivation by a photosensitizer (PS) at a specific wavelength (λ) of light in the vicinity of molecular oxygen (singlet oxygen). The cell death mechanisms adopted in PDT upon PS photoactivation are necrosis, apoptosis and stimulation of the immune system. Over the past few decades, the use of natural compounds as a photoactive agent for the selective eradication of neoplastic lesions has attracted researchers’ attention. Many reviews have focused on the PS cell death mode of action and photonanomedicine approaches for PDT, while limited attention has been paid to the photoactivation of phytocompounds. Photoactivation is ever-present in nature and also found in natural plant compounds. The availability of various laser light setups can play a vital role in the discovery of photoactive phytocompounds that can be used as a natural PS. Exploring phytocompounds for their photoactive properties could reveal novel natural compounds that can be used as a PS in future pharmaceutical research. In this review, we highlight the current research regarding several photoactive phytocompound classes (furanocoumarins, alkaloids, poly-acetylenes and thiophenes, curcumins, flavonoids, anthraquinones, and natural extracts) and their photoactive potential to encourage researchers to focus on studies of natural agents and their use as a potent PS to enhance the efficiency of PDT.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
5.4
作者：
Ailioaie LM;Ailioaie C;Litscher G
通讯作者：
Litscher G
影响因子：
5.4
作者：
ALADE, PI;IROBI, ON
通讯作者：
IROBI, ON
影响因子：
5.4
作者：
Bark, Ki-Min;Heo, Eun Phil;Kim, Tae Heung
通讯作者：
Kim, Tae Heung
影响因子：
3.3
作者：
Abdulrahman, Hayder;Misba, Lama;Khan, Asad U.
通讯作者：
Khan, Asad U.