课题基金 / 基金详情

Molecular mechanisms controlling the signaling efficacy and selectivity of dynamic G protein-coupled receptor signaling complexes

Molecular mechanisms controlling the signaling efficacy and selectivity of dynamic G protein-coupled receptor signaling complexes
控制动态 G 蛋白偶联受体信号复合物信号传导功效和选择性的分子机制
批准号：
200947
负责人：
Bouvier Michel
金额：
$75.76万
依托单位：
Universit de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2010
资助国家：
加拿大
项目状态：
已结题
起止时间：
2010-03-01 至 2015-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=200947&lang=en
关键词：
Biochemistry Durg Targets G Protein-Coupled Receptors Molecular Pharmacology Protein-Protein Interaction Receptor Trafficking Resonance Energy Transfer Signal Transduction

项目摘要

项目成果

Bouvier Michel的其他基金

相关文献

中文摘要
翻译
对于许多临床适应症来说，发现和开发治疗效果更好、不良反应更少的新药仍然是一个未得到满足的需求。近年来，真正创新药物的发现和商业化的速度已经很快。
英文摘要
The discovery and development of new drugs with better therapeutic efficacy and lesser undesirable effects remains an unmet need for many clinical indications. In recent years, the rate of discovery and commercialization of truly innovative drugs has sens
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Molecular mechanisms and structural determinants of pharmacological chaperone action; therapeutic potential for the treatment of early onset severe obesity
Mechanisms and consequences of spatially controlled G protein-coupled receptor signaling
G protein functional selectivity in metabolic disorders
A novel paradigm for effective and safer treatment of schizophrenia: biased (ant)agonists with a characterized polypharmacological profile