Novel compounds to disrupt protein-protein interactions

许多疾病涉及蛋白质之间的异常相互作用。抑制这种相互作用的策略有潜力作为生物学研究的工具试剂，也有可能作为新的治疗方法。目前临床上使用的大多数药物都是小有机分子，尽管这些药物通常不能有效地破坏蛋白质复合物，因此需要替代品。研究折叠体作为一种抑制蛋白质的新策略的建议：蛋白质相互作用可能导致新药的开发，用于治疗目前传统方法无效的疾病。

Many diseases involve aberrant interactions between proteins. Strategies to inhibit such interactions have potential as tool reagents for biological research but also as new therapies. Most drugs currently used in the clinic are small organic molecules, though these typically are not effective at disrupting protein complexes, hence alternatives are required. This proposal to examine foldamers as a novel strategy for inhibiting protein: protein interactions could lead to the development of new drugs for the treatment of diseases where the current traditional approaches have proven ineffective.