Studies on peripheral T cell memory

疫苗接种的成功与否取决于免疫系统是否有能力记住先前与感染因子的接触。这种免疫记忆似乎对某些感染有效，但对其他感染不起作用，这基本上意味着，对于这些疾病，仍然没有有效的疫苗。本应用程序描述了基于免疫记忆研究中被忽视的一种新的白细胞或白细胞群的实验。这项工作包括确定它们是如何形成的以及它们在体内的行为。因此，这项工作将有助于开发和生产针对这些迄今无法控制的传染病的新一代疫苗。

Success in vaccination depends on the ability of the immune system to remember prior encounter with an infectious agent. This immune memory appears to work well for certain infections but not others, essentially meaning that for these diseases, effective vaccines remain unavailable. This application describes experiments based on a new leukocyte or white blood cell population that has been overlooked in studies of immune memory. The work involves identifying how they are formed and how they behave within the body. This work will therefore contribute to the development and production of new-generation vaccines to these so far uncontrollable infectious diseases.