Development of technologies to monitor multimolecular complexes

发展监测多分子复合物的技术。该项目旨在开发技术来监测蛋白质及其相互作用分子（如激素）如何形成多组分复合物，以及这些复合物如何在细胞中发挥作用，包括从细胞表面移动到不同的细胞隔室并返回表面。预计这些技术将能够以高灵敏度实时监测活细胞。这一项目可能对细胞和分子水平上生命科学的所有方面的研究产生广泛的惠益和影响。这些蛋白质复合物在细胞中的功能是我们对生物学和技术工具的理解的基础。

Development of technologies to monitor multimolecular complexes. This project aims to develop technologies to monitor how proteins and their interacting molecules (such as hormones) form multi-component complexes, and how these complexes function in the cell, including movement from the cell surface, into different cellular compartments and back up to the surface. These technologies are expected to enable monitoring in live cells in real-time with high sensitivity. This project could have broad benefits for and affect study of all aspects of the life sciences at the cellular and molecular levels. How these protein complexes function in cells underpins much of our understanding of biology, and technological tools.