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Molecular mechanisms underlying high-affinity and isotype switched antibody responses

Molecular mechanisms underlying high-affinity and isotype switched antibody responses
高亲和力和同种型转换抗体反应的分子机制
批准号：
479363
负责人：
Di Noia Javier M
金额：
$61.86万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-03-01 至 2028-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=479363&lang=en
关键词：
Activation Induced Deaminase Antibody Responses B Cell Lymphoma Class Switch Recombination Dna Damage Germinal Center Mutagenesis Proteomics Somatic Hypermutation

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中文摘要
翻译
抗体介导了大多数疫苗的大部分保护作用，是抵御病原体和毒素的主要防线，并提供免疫记忆以防止再次感染。为了有效，抗体需要与目标致病组织结合
英文摘要
Antibodies mediate much of the protective effect of most vaccines, are a major line of defence against pathogens, and toxins, and provide immunological memory to prevent reinfections. To be effective, antibodies need to bind to their target pathogenic org
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