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Investigating the role of TRAF7 in regulating antiviral immune response

Investigating the role of TRAF7 in regulating antiviral immune response
研究 TRAF7 在调节抗病毒免疫反应中的作用
批准号：
433070
负责人：
Lin Rongtuan
金额：
$60.47万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2020
资助国家：
加拿大
项目状态：
未结题
起止时间：
2020-10-01 至 2025-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=433070&lang=en
关键词：
Hsv-1 Influenza Virus Innate Immunity Interferons Sting Tamoxifen-Inducible Cre+/-Traf7flox/Flox Mice Tbk1 Traf7 Ubiquitination Virus Infection

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中文摘要
翻译
I型干扰素是宿主对抗病毒感染所必需的。然而，过量的IFN I产生在更坏的情况下导致组织损伤或自身免疫性疾病。为了确保成功的抗病毒防御，
英文摘要
type I interferons is essential for host to fight against viral infection. However, the excessive IFN I production results in either tissue damage or autoimmune diseases under worse condition. To ensure successful antiviral defenses and to avoid aberrant
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