Influenza virus and viral RNA induced activation of innate immunity

流感病毒和病毒RNA诱导先天免疫激活

• 批准号: 212142474
• 负责人: Professor Dr. Stephan Ludwig
• 金额: --
• 依托单位: Fachgebiet 17: Influenzaviren und weitere Viren des Respirationstraktes
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/212142474?language=en
• 关键词: Influenza; virus; viral; RNA; induced

Influenza viruses are globally very important pathogens causing yearly epidemics and occasional pandemic that may lead to significant morbidity and mortality. At present, vaccines, antiviral substances and social isolation are the means to prevent and treat influenza infections in a society. To better fight against influenza virus infections we need better understanding of the basic mechanisms of virus replication, viral – host interactions and activation of host immune responses. The present project will take place as a collaborative network between Finnish, German and Chinese research group that are among the leaders of their fields in influenza virology, innate immunity, RNA biology and experimental mouse infection research. The research groups will characterize the activation of host innate immune responses in human cellular models and mouse animal experiments. The functions of cellular receptors and antiviral molecules that are activated by influenza viruses and/or their genetic material will be characterized. The work will provide information on the mechanisms of activation and inhibition of innate immune responses during influenza infection and the data obtained in the project is likely to lead to novel innovations and a better means to treat and prevent severe influenza virus infections.

流感病毒是全球范围内非常重要的病原体，每年引起流行病和偶尔的大流行，可能导致显著的发病率和死亡率。目前，疫苗、抗病毒物质和社会隔离是一个社会预防和治疗流感感染的手段。为了更好地对抗流感病毒感染，我们需要更好地了解病毒复制、病毒与宿主相互作用和宿主免疫应答激活的基本机制。本项目将作为芬兰、德国和中国研究小组之间的合作网络进行，这些研究小组在流感病毒学、先天免疫、RNA生物学和实验小鼠感染研究领域处于领先地位。研究小组将在人类细胞模型和小鼠动物实验中表征宿主先天免疫反应的激活。将表征被流感病毒和/或其遗传物质激活的细胞受体和抗病毒分子的功能。这项工作将提供有关流感感染期间先天免疫反应激活和抑制机制的信息，该项目中获得的数据可能会导致新的创新和更好的治疗和预防严重流感病毒感染的方法。