Suspension Polymerization of Hydrophilic Monomers

PI建议研究亲水性（遇水膨胀） 通过悬浮聚合制备微粒。 等 聚合物颗粒具有许多实际用途，包括：（1）在 小分子量或大分子量的色谱分离 溶质;（2）作为离子交换树脂;（3）作为填充材料， 填充床反应器;（4）作为脱模剂， 海洋科学中的涂料;（5）作为酶的载体 固定化;（6）作为药物的释放剂， （7）在反应工程中作为催化剂。 微粒的结构和几何特征 在任何情况下都影响其可用性。 在悬浮聚合中，反应在有机溶剂中进行。 悬浮在无机相中的单体相;通常 水 产物固体聚合物沉淀出来并含有 少量（10%）未反应的单体。 所需产物 已控制：粒度分布、形状、孔径 分布、分子量分布和分子量 在交叉连接之间。 在这项研究中，PI计划做动力学 亲水性单体的间歇悬浮聚合的建模。 具体而言，这项工作将包括以下活动： I. 发展适用的动力学模型 聚合/交联反应的亲水性 单体与交联剂，在交联之前和之后， 胶凝点，直至玻璃化; 二. 分子量分布的测定 在凝胶化点之前的产物作为 反应的动力学常数和反应的进料比 单体; 三.反应工程模型的发展 在间歇式反应器中的悬浮聚合; 四. 确定影响的关键参数 在这种类型的悬浮液中的颗粒尺寸分布 聚合; 诉 进行悬浮聚合实验， 甲基丙烯酸羟乙酯（HEMA）和乙二醇 二甲基丙烯酸酯（EGDMA）作为交联剂和测定 颗粒和分子量的在线或离线 分发;以及 六. 系统方程的预测与 EGDMA/HEMA批料悬浮液的实验结果 聚合。

The PI proposes to study hydrophilic (water swellable) microparticle production by suspension polymerization. Such polymer particles have many practical uses including: (1) in chromatographic separations of small or large molecular weight solutes; (2) as ion-exchange resins; (3) as filling materials in packed bed reactors; (4) as releasing agents for antifouling paints in marine science; (5) as carriers for enzyme immobilization; (6) as releasing agents for drugs in pharamaceuticals; and (7) as catalysts in reaction engineering. Structural and geometric characteristics of the microparticles affect their usability in all cases. In suspension polymerization, reaction takes place in an organic monomer phase which is suspended in an inorganic phase; usually water. The product solid polymer precipitates out and contains small amounts (10%) of unreacted monomer. The desired products have controlled: particle size distribution, shape, pore size distribution, molecular weight distribution and molecular weight between crosslinks. In this research the PI plans to do kinetic modelling of batch suspension polymerizations of hydrophilic monomers. Specifically, the work will include the following activities: i. development of the kinetic models applicable to the copolymerization/crosslinking reaction of a hydrophilic monomer with a crosslinking agent, both before and after the gelation point and until vitrification; ii. determination of the molecular weight distribution of the product before the gelation point as a function of the kinetic constants of the reactions and the feed ratio of the monomers; iii. development of the models for reaction engineering in suspension polymerization in batch reactors; iv. determination of the critical parameters that affect the particle size distribution in this type of suspension polymerizations; v. conduct experiments of suspension polymerizations with 2- hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) as a crosslinking agent and determination on- or off-line of the particle and molecular weight distributions; and vi. comparison of the predictions of the system equations with experimental results for EGDMA/HEMA batch suspension polymerizations.