Presidential Young Investigator Award/Analytical Chemistry with Microelectrodes.

该项目属于分析化学和表面化学的一般领域，以及电化学和分离科学的子领域。这项研究涉及三个具有技术和基本重要性的领域。在第一个领域，将设计和表征极小的微伏安法探针，并评估它们在体内动态定量细胞内神经递质的用途。在第二个领域，将开发毛细管区带电泳法和微柱开管液相色谱方法，用于分析超小体积样品。与新开发的电化学检测器相结合，这些方法应该能够检测氧化还原活性分析物的亚毫微摩尔浓度，并为神经递质分析提供一种静态定量方法，以补充已经描述的动态方法。第三，我们将研究茂金属衍生磷腈和磷腈聚合物独特的电化学行为，并评价它们作为电荷存储介质的潜在用途。这笔为期五年的持续拨款给宾夕法尼亚州立大学，以支持尤因教授担任总统青年研究员，旨在使他能够快速有效地启动这一广泛和创新的化学研究计划。

This project is in the general area of analytical and surface chemistry and in the subfields of electrochemistry and separation science. Three areas of technological and fundamental importance are addressed by this research. In the first area, extremely small microvoltammetric probes will be disigned and characterized and their use for the dynamic in vivo quantification of intracellular neurotransmitters will be evaluated. In a second area, capillary zone electrophoretic and microcolumn open-tubular liquid chromatographic protocols will be developed for the analysis of ultra-small-volume samples. Coupled with newly developed electrochemical detectors, these methods should permit the detection of sub-femtomolar concentrations of redox-active analytes and provide a static quantitative method for neurotransmitter analysis to complement the dynamic approach already described. Thirdly, the unique electrochemical behavior of metallocene-derivatized phosphazenes and phosphazene polymers will be investigated and their potential utility as charge storage media evaluated. This five year continuing grant to The Pennsylvania State University for the support of Professor Ewing as a Presidential Young Investigator is designed to enable his rapid and effective initiation of this broad and innovative research program in chemistry.