Stereochemical Purification of an Anti-Inflammatory Drug in an Enzyme Membrane Reactor

药品的销售价格很大程度上受到产品提纯成本的影响--即将所需的化学物质从生产它的反应介质中分离出来。该项目是对生物反应器的研究，该生物反应器将生产和分离阶段结合在一个单元中，从而可以极大地降低消费者的最终成本。这种高成本的部分原因是新药的复杂性增加，通常是以多种构型(异构体)存在的非常复杂的分子。在这些化合物中，通常只有一种构型具有所需的性质，并且除了将不同的化合物彼此分离时所遇到的困难之外，将它们彼此分开会导致额外的困难。要考虑的配置是中空纤维模块，其中酶(生物催化剂)被固定，产品被连续移除。这也有一个好处，那就是产品浓度不会增加，这通常会抑制酶的活性。PI计划在这一阶段的工作中测量酶的活性和立体选择性，并运行一个原型反应器。他们很有资格做这项研究，设施也很充足。建议提供资金。

The sale price of drugs is strongly affected by the cost of purifying the product - i.e. separating the desired chemical from the reaction medium in which it is produced. This project is a study of a bioreactor that combines the production and separation stages in one unit and thus could greatly decrease final costs to consumers. Some of this high cost is due to the increased complexity of new drugs, often very complicated molecules which may exist in more than one configuration (isomer). Of these, often only one configuration has the desired properties and separating them from each other results in additional difficulties over and above those encountered when separating different compounds from each other. The configurations to be looked at are hollow-fiber modules where the enzymes (the biocatalysts) are immobilized and product is continuously removed. This has the advantage also that product concentration does not build up which normally inhibits enzyme activity. The PIs plan to measure enzyme activity and stereoselectivity and to operate a prototype reactor in this Phase I work. They are well qualified to do the research and the facilities are adequate. Funding is recommended.