U.S.-Korea Cooperative Research on Protein Interactions withGradient Surfaces

该提案要求获得资金，以允许犹他大学生物工程系Joseph D.Andrade博士与韩国化学技术研究院聚合物实验室Hai Bang Lee博士进行为期24个月的关于蛋白质与梯度表面相互作用的合作研究计划。合作者将制备和表征具有一系列连续表面性质的样品，并研究一组蛋白质与这些表面的相互作用。美国队将通过溶液工艺准备表面，而韩国队将使用“干燥”真空工艺。两个小组都将研究表面特征--美国小组研究蛋白质吸附，韩国小组研究蛋白质处理前后表面细胞黏附。两个小组都将致力于数据解释和假设完善。蛋白质在固-液界面上的吸附在许多应用和工业中都很重要，包括分离、生物技术、医疗设备和诊断产品。合作者是长期从事聚合物研究的备受尊敬的科学家。本项目将使他们能够以互补的方式结合他们的才华来研究研究问题。该项目与美韩合作科学计划的目标相关，该计划旨在通过交流科学信息、想法、技能和技术以及通过在互利问题上的合作来提高美国和韩国科学家和工程师之间的合作水平。

This proposal requests funds to permit Dr. Joseph D. Andrade, Department of Bioengineering, University of Utah, to pursue with Dr. Hai Bang Lee, Polymer Laboratory, Korea Research Institute of Chemical Technology, for a period of 24 months, a program of cooperative research on protein interactions with gradient surfaces. The collaborators will prepare and characterize samples which exhibit a continuous range of surface properties and study the interactions of a set of proteins with these surfaces. The U.S. team will prepare surfaces by a solution process, while the Korean team will use a "dry" vacuum process. Both groups will study surface characterization - the U.S. group studying protein adsorption, the Korean group studying cell adhesion on surfaces before and after protein treatment. Both group will work on data interpretation and hypothesis refinement. Protein adsorption at solid-liquid interfaces is important in many applications and industries, including separations, biotechnology, medical devices, and diagnostic products. The collaborators are highly respected scientists who have long been engaged in polymer research. The present project will allow them to combine their talents in complimentary approaches to a study of the research problem. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit.