New Polyamides with a Protein-Like Structure

这项工作旨在设计基于序列残基的新型聚酰胺，类似于在蛋白质中发现的那些残基。人们期望找到新的构象，与标准尼龙和蛋白质中存在的构象相关或不同，从而产生新的性能。对于这些聚合物的表征，傅里叶变换红外光谱，圆二色性（如适用），溶液和固态核磁共振，电子显微镜和纤维衍射技术将被强调。研究人员还将利用计算机模拟来确定新聚合物的首选结构。这些聚合物在缝合线、构象和性能方面具有潜在的用途，新型的拟肽聚酰胺将被设计出来。

This work is directed toward the design of novel polyamides based on the incorporation of sequential residues, similar to those found in proteins. One expects to find new conformations, related to or different from those present in standard nylons and proteins, which will result in new properties. For the characterization of these polymers, Fourier transform infrared spectroscopy, circular dichroism (where applicable), solution and solid state nuclear magnetic resonance, electron microscopy, and fiber-diffraction techniques will be emphasized. The investigators will also utilize computer simulations to determine the preferred structures of the new polymers. These polymers should have potential uses as sutures, conformation, and properties, new classes of peptidomimetic polyamides will be designed.